Peppard R J, Karn C A, McCabe M A, Wassall S R, Liechty E A, Denne S C
Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202-5210.
J Pediatr. 1993 Sep;123(3):457-62. doi: 10.1016/s0022-3476(05)81756-1.
To assess whether a simple nonrestrictive method of determining nutrient intake could be applied to premature infants, we compared actual measured formula intake during a 7-day period with intake calculated from deuterium dilution in 13 hospitalized, growing, premature newborn infants. An oral dose of deuterium oxide (D2O) was administered, and urine samples were analyzed by deuterium nuclear magnetic resonance spectrometry for D2O concentration. Using an exponential model, we calculated formula intake from the decline in D2O concentration during the 7-day study period. Intake as assessed by the deuterium model correlated well with actual intake (r = 0.93; p < 0.001). However, because the deuterium dilution model measures both dietary and nondietary water intake (metabolic and cutaneous water influx), deuterium dilution-derived intake exceeded actual intake by 25 +/- 18 ml/kg per day (16% +/- 11%). When corrections were applied to account for nondietary water intake, deuterium dilution-derived nutrient intake (160 +/- 30 ml/kg per day) closely approximated actual intake (155 +/- 17 ml/kg per day). If corrections are made for nondietary water intake, the deuterium dilution method may be a useful nonrestrictive method of measuring nutrient intake in a variety of neonatal populations.
为评估一种简单的非限制性营养摄入量测定方法是否可应用于早产儿，我们将13名住院的、正在成长的早产新生儿在7天内实际测量的配方奶摄入量与通过氘稀释法计算的摄入量进行了比较。口服一剂氧化氘（D2O），并通过氘核磁共振光谱法分析尿样中的D2O浓度。使用指数模型，我们根据7天研究期间D2O浓度的下降计算配方奶摄入量。通过氘模型评估的摄入量与实际摄入量相关性良好（r = 0.93；p < 0.001）。然而，由于氘稀释模型同时测量饮食和非饮食水分摄入量（代谢和皮肤水分流入），氘稀释法得出的摄入量比实际摄入量每天高出25±18 ml/kg（16%±11%）。当对非饮食水分摄入量进行校正时，氘稀释法得出的营养摄入量（每天160±30 ml/kg）与实际摄入量（每天155±17 ml/kg）非常接近。如果对非饮食水分摄入量进行校正，氘稀释法可能是一种用于测量各种新生儿群体营养摄入量的有用的非限制性方法。
