The Second Affiliated Hospital of Shandong First Medical University, No. 366 Taishan Street, Tai'an, Shandong 271000, China.
Contrast Media Mol Imaging. 2022 Jun 3;2022:3977289. doi: 10.1155/2022/3977289. eCollection 2022.
This study systematically reviewed the effect of DNA methylation in the promoter region of the coagulation factor vWF gene on the risk of unexplained recurrent hemophilia. PubMed, Medline, Web of Science, and other computers were used to search the database, and the statistical randomized controlled trials of coagulation factor vWF in the risk analysis of unknown recurrent hemophilia were collected. The Cochrane systematic evaluation method was used to evaluate the quality of the included kinds of literature, and Revman5 software was used to sort out and analyze the kinds of literature. Meta-analysis showed that there was a statistical difference between the experimental group and the control group in case fatality rate (OR = 1.76, 95% CI (1.29, 2.39), =0.0003, = 0%, = 3.58), adverse events (OR = 2.38, 95% CI (1.65, 3.45), < 0.00001, = 0%, = 4.60), incidence of joint hemorrhage (OR = 2.52, 95% CI (1.62, 3.91), < 0.00001, = 0%, = 4.12), incidence of subcutaneous stasis (OR = 1.76, 95% CI (1.26, 2.45), =0.0009, = 5%, = 3.33), and hematoma volume (OR = 1.78, 95% CI (1.32, 2.40), =0.0001, = 23%, = 3.80). DNA methylation in the promoter region of the coagulation factor vWF gene was significantly associated with the risk of unexplained recurrent hemophilia. Whether demethylation can improve the bleeding index of patients with recurrent hemophilia remains to be further explored.
本研究系统地回顾了凝血因子 vWF 基因启动子区域的 DNA 甲基化对不明原因复发性血友病风险的影响。使用 PubMed、Medline、Web of Science 等计算机检索数据库，收集凝血因子 vWF 在不明原因复发性血友病风险分析中的随机对照试验统计资料。采用 Cochrane 系统评价方法评价纳入文献的质量，Revman5 软件对文献进行整理分析。Meta 分析显示，实验组与对照组病死率差异有统计学意义（OR=1.76，95%CI（1.29，2.39），=0.0003， =0%， =3.58），不良事件（OR=2.38，95%CI（1.65，3.45）， < 0.00001， =0%， =4.60），关节出血发生率（OR=2.52，95%CI（1.62，3.91）， < 0.00001， =0%， =4.12），皮下瘀斑发生率（OR=1.76，95%CI（1.26，2.45）， =0.0009， =5%， =3.33），血肿体积（OR=1.78，95%CI（1.32，2.40）， =0.0001， =23%， =3.80）。凝血因子 vWF 基因启动子区的 DNA 甲基化与不明原因复发性血友病的风险显著相关。去甲基化是否能改善复发性血友病患者的出血指数仍有待进一步探讨。
