• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Remestemcel-L allogeneic bone marrow-derived mesenchymal stem cell product to treat medically refractory Crohn's colitis: preliminary phase IB/IIA study.

作者信息

Lightner Amy L, Ream Justin, Nachand Douglas, Fulmer Clifton, Regueiro Miguel, Steele Scott R

机构信息

Department of Colorectal Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Ohio, USA.

Department of Radiology, Imaging Institute, Cleveland Clinic, Ohio, USA.

出版信息

Br J Surg. 2022 Jul 15;109(8):653-655. doi: 10.1093/bjs/znac078.

DOI:10.1093/bjs/znac078
PMID:35714218
Abstract
摘要

相似文献

1
Remestemcel-L allogeneic bone marrow-derived mesenchymal stem cell product to treat medically refractory Crohn's colitis: preliminary phase IB/IIA study.用于治疗难治性克罗恩病结肠炎的Remestemcel-L同种异体骨髓间充质干细胞产品：IB/IIA期初步研究。
Br J Surg. 2022 Jul 15;109(8):653-655. doi: 10.1093/bjs/znac078.
2
Comments on: "A Phase IB/IIA Study of Ex Vivo Expanded Allogeneic Bone-Marrow Derived Mesenchymal Stem Cells for the Treatment of Perianal Fistulizing Crohn's Disease".关于《一项关于体外扩增的同种异体骨髓间充质干细胞治疗肛周瘘管型克罗恩病的ⅠB/ⅡA期研究》的评论
Dis Colon Rectum. 2024 Mar 1;67(3):e202. doi: 10.1097/DCR.0000000000003176. Epub 2023 Dec 5.
3
A phase IB/IIA study of remestemcel-L, an allogeneic bone marrow-derived mesenchymal stem cell product, for the treatment of medically refractory ulcerative colitis: an interim analysis.一项关于 remestemcel-L（一种同种异体骨髓来源的间充质干细胞产品）治疗药物难治性溃疡性结肠炎的 Ib/IIa 期研究：中期分析。
Colorectal Dis. 2022 Nov;24(11):1358-1370. doi: 10.1111/codi.16239. Epub 2022 Jul 19.
4
Comment on "A phase IB/IIA study of ex vivo expanded allogeneic bone-marrow-derived mesenchymal stem cells for the treatment of rectovaginal fistulizing Crohn disease.".关于“一项关于体外扩增的同种异体骨髓间充质干细胞治疗直肠阴道瘘型克罗恩病的ⅠB/ⅡA期研究”的评论
Surgery. 2024 May;175(5):1463-1464. doi: 10.1016/j.surg.2023.10.038. Epub 2023 Dec 2.
5
A Phase IB/IIA Study of Allogeneic, Bone Marrow-derived, Mesenchymal Stem Cells for the Treatment of Refractory Ileal-anal Anastomosis and Peripouch Fistulas in the Setting of Crohn's Disease of the Pouch.骨髓源性异体间充质干细胞治疗克罗恩病术后吻合口和吻合口周围瘘的 I 期/II 期研究
J Crohns Colitis. 2023 Apr 19;17(4):480-488. doi: 10.1093/ecco-jcc/jjac172.
6
A phase IB/IIA study of ex vivo expanded allogeneic bone marrow-derived mesenchymal stem cells for the treatment of rectovaginal fistulizing Crohn's disease.一项关于异体骨髓源性间充质干细胞体外扩增治疗直肠阴道瘘型克罗恩病的 Ib/IIa 期研究。
Surgery. 2024 Feb;175(2):242-249. doi: 10.1016/j.surg.2023.07.020. Epub 2023 Sep 1.
7
Direct Injection of Ex Vivo Expanded Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells for the Treatment of Pediatric Crohn's Perianal Fistulizing Disease.直接注射体外扩增的同种异体骨髓间充质干细胞治疗小儿克罗恩病肛周瘘管病
Dis Colon Rectum. 2024 Feb 1;67(2):e115-e116. doi: 10.1097/DCR.0000000000002767. Epub 2023 Sep 19.
8
Remestemcel-L: human mesenchymal stem cells as an emerging therapy for Crohn's disease.Remestemcel-L：人骨髓间充质干细胞作为一种新兴的克罗恩病治疗方法。
Expert Opin Biol Ther. 2011 Sep;11(9):1249-56. doi: 10.1517/14712598.2011.602967. Epub 2011 Jul 25.
9
Treatment of Steroid-Refractory Acute Graft--Host Disease Using Commercial Mesenchymal Stem Cell Products.使用商业间充质干细胞产品治疗激素难治性急性移植物抗宿主病。
Front Immunol. 2021 Aug 19;12:724380. doi: 10.3389/fimmu.2021.724380. eCollection 2021.
10
A Phase 3 Randomized Study of Remestemcel-L versus Placebo Added to Second-Line Therapy in Patients with Steroid-Refractory Acute Graft-versus-Host Disease.一项关于在类固醇难治性急性移植物抗宿主病患者中，将remestemcel-L与安慰剂添加到二线治疗方案进行对比的3期随机研究。
Biol Blood Marrow Transplant. 2020 May;26(5):835-844. doi: 10.1016/j.bbmt.2019.08.029. Epub 2019 Sep 7.

引用本文的文献

1
Mesenchymal stem cells in treating human diseases: molecular mechanisms and clinical studies.间充质干细胞在治疗人类疾病中的应用：分子机制与临床研究
Signal Transduct Target Ther. 2025 Aug 22;10(1):262. doi: 10.1038/s41392-025-02313-9.
2
Clinical Progress in Mesenchymal Stem Cell Therapy: A Focus on Rheumatic Diseases.间充质干细胞治疗的临床进展：聚焦于风湿性疾病
Immun Inflamm Dis. 2025 May;13(5):e70189. doi: 10.1002/iid3.70189.
3
Insights into Modeling Inflammatory Bowel Disease from Stem Cell Derived Intestinal Organoids.从干细胞衍生的肠道类器官对炎症性肠病建模的见解。
Stem Cell Rev Rep. 2025 Apr 29. doi: 10.1007/s12015-025-10887-8.
4
Optimization of transplantation methods using isolated mesenchymal stem/stromal cells: clinical trials of inflammatory bowel diseases as an example.使用分离的间充质干/基质细胞优化移植方法：以炎症性肠病的临床试验为例
Inflamm Regen. 2024 Aug 16;44(1):37. doi: 10.1186/s41232-024-00350-5.
5
Stem Cells and Stem Cell-Derived Factors for the Treatment of Inflammatory Bowel Disease with a Particular Focus on Perianal Fistulizing Disease: A Minireview on Future Perspectives.干细胞及其衍生因子治疗炎症性肠病，特别是肛周瘘管病：未来展望的小型综述。
BioDrugs. 2024 Jul;38(4):527-539. doi: 10.1007/s40259-024-00661-6. Epub 2024 Jun 25.
6
Patient engagement and satisfaction with early phase cell therapy clinical trials at a tertiary inflammatory bowel disease center.在一家三级炎症性肠病中心，患者对早期细胞治疗临床试验的参与度和满意度。
Stem Cell Reports. 2024 Apr 9;19(4):435-442. doi: 10.1016/j.stemcr.2024.02.008. Epub 2024 Mar 28.
7
Efficacy and safety of stem cell therapy for Crohn's disease: a meta-analysis of randomized controlled trials.干细胞治疗克罗恩病的疗效和安全性：一项随机对照试验的荟萃分析。
Stem Cell Res Ther. 2024 Feb 2;15(1):28. doi: 10.1186/s13287-024-03637-z.
8
Clinical application prospects and transformation value of dental follicle stem cells in oral and neurological diseases.牙囊干细胞在口腔及神经疾病中的临床应用前景与转化价值
World J Stem Cells. 2023 Apr 26;15(4):136-149. doi: 10.4252/wjsc.v15.i4.136.