Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China.
Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China.
J Control Release. 2022 Aug;348:572-589. doi: 10.1016/j.jconrel.2022.06.014. Epub 2022 Jun 18.
Great attention has been paid to the impressive role the macromolecules played in cancer immunotherapy, however, the applications were largely limited by their poor circulation stability, low cellular uptake efficiency, and off-target effects. As an important messenger of intercellular communication, extracellular vesicles (EVs) exhibit unique advantages in macromolecule delivery compared to traditional synthetic carriers, offering new possibilities for modern drug delivery. These naturally derived carriers can achieve stable, efficient, and selective delivery of macromolecules and improve the efficacy and potentiality of macromolecular drugs in cancer immunotherapy. This review provides a brief overview of the unique features of EVs related to macromolecule delivery, the strategies and recent advances of using EVs as macromolecule delivery carriers in cancer immunotherapy.
人们对大分子在癌症免疫治疗中发挥的令人印象深刻的作用给予了极大关注，但由于其循环稳定性差、细胞摄取效率低和脱靶效应，其应用受到了很大限制。作为细胞间通讯的重要信使，与传统的合成载体相比，细胞外囊泡（EVs）在大分子递送上具有独特的优势，为现代药物递送提供了新的可能。这些天然衍生的载体可以实现大分子的稳定、高效和选择性递送，并提高大分子药物在癌症免疫治疗中的疗效和潜力。本文简要概述了 EVs 在大分子递送上的独特特征，以及利用 EVs 作为大分子药物载体在癌症免疫治疗中的策略和最新进展。
