Multimodal Research Area, Bambino Gesù Children Hospital IRCCS, Rome, Italy.
Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
Sci Rep. 2022 Jun 17;12(1):10194. doi: 10.1038/s41598-022-14426-0.
Since the start of SARS-CoV-2 pandemic, children aged ≤ 12 years have always been defined as underrepresented in terms of SARS-CoV-2 infections' frequency and severity. By correlating SARS-CoV-2 transmission dynamics with clinical and virological features in 612 SARS-CoV-2 positive patients aged ≤ 12 years, we demonstrated a sizeable circulation of different SARS-CoV-2 lineages over the four pandemic waves in paediatric population, sustained by local transmission chains. Age < 5 years, highest viral load, gamma and delta clades positively influence this local transmission. No correlations between COVID-19 manifestations and lineages or transmission chains are seen, except for a negative correlation between B.1.1.7 and hospitalization.
自 SARS-CoV-2 大流行开始以来，年龄≤12 岁的儿童在 SARS-CoV-2 感染的频率和严重程度方面一直被认为代表性不足。通过将 SARS-CoV-2 传播动力学与 612 名年龄≤12 岁的 SARS-CoV-2 阳性患者的临床和病毒学特征相关联，我们证明了在儿科人群中，不同的 SARS-CoV-2 谱系在四次大流行波中持续存在，这是由本地传播链维持的。年龄<5 岁、病毒载量最高、伽马和德尔塔谱系均对这种本地传播产生积极影响。在 COVID-19 表现和谱系或传播链之间没有相关性，除了 B.1.1.7 与住院之间的负相关。
