Behavioral Science Institute, Radboud University, Nijmegen, the Netherlands; Department of Psychology, Education, and Child Studies, Erasmus University Rotterdam, the Netherlands; Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Dev Cogn Neurosci. 2022 Aug;56:101120. doi: 10.1016/j.dcn.2022.101120. Epub 2022 Jun 10.
Psychosocial acceleration theory suggests that early stress accelerates pubertal development. Using half of the baseline Adolescent Brain and Cognitive Development (ABCD) cohort, Thijssen et al. (2020) provide support that accelerated puberty following stressful family environments may promote neurodevelopment. Here, we replicate and extend those analyses using 1) data from the second half of the ABCD sample (n = 3300 +, ages 9-10), and 2) longitudinal imaging data from the original sample (n = 1800 +, ages 11-12). A family environment latent variable was created and related to anterior cingulate cortex (ACC) thickness, area, white matter fractional anisotropy, amygdala volume, and cingulo-opercular network (CON)-amygdala resting-state functional connectivity. Results from the independent sample replicate the mediating effects of family environment through pubertal stage on amygdala-CON functional connectivity. Sex-stratified analyses show indirect effects via pubertal stage in girls; boys show evidence for direct associations. Analyses using wave 2 imaging data or wave 2-wave 1 difference scores from the originally-analyzed sample replicate the resting-state indirect effects. The current paper replicates the mediating role for puberty in the association between family environment and neurodevelopment. As both direct and indirect associations were found, puberty may be one of multiple mechanisms driving accelerated neurodevelopment following environmental stress.
心理社会加速理论表明，早期压力会加速青春期发育。Thijssen 等人（2020 年）使用青少年大脑与认知发展研究（ABCD）的一半基线队列提供了支持，即压力大的家庭环境后加速的青春期发育可能促进神经发育。在这里，我们使用 1）ABCD 样本的后半部分的数据（n=3300+，年龄 9-10 岁）和 2）原始样本的纵向成像数据（n=1800+，年龄 11-12 岁）来复制和扩展这些分析。创建了一个家庭环境潜在变量，并将其与前扣带皮层（ACC）厚度、面积、白质各向异性分数、杏仁核体积和扣带-杏仁核静息态功能连接相关联。来自独立样本的结果复制了家庭环境通过青春期阶段对杏仁核-扣带功能连接的中介效应。性别分层分析显示，女孩通过青春期阶段存在间接影响；男孩则存在直接关联的证据。使用第 2 波成像数据或最初分析样本的第 2 波-第 1 波差值分数进行的分析复制了静息态的间接效应。本研究复制了青春期在家庭环境与神经发育之间的关联中的中介作用。由于发现了直接和间接的关联，青春期可能是环境压力后加速神经发育的多种机制之一。
