Yang Yumeng, Kong Tianjiao, Liu Ran, Luo Liang
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Institute of Developmental Psychology, Faculty of Psychology, Beijing Normal University, Beijing, China.
Transl Psychiatry. 2025 May 16;15(1):168. doi: 10.1038/s41398-025-03384-6.
Early life adversity (ELA) is highly prevalent and has significant detrimental effects on children's brain development and behavioral outcomes. However, associations of threat, unpredictability, and deprivation in dimensional models of ELA with corticolimbic circuits were unclear. Previous studies have highlighted the effects of proximity, especially the distinctions between interpersonal and socioeconomic ELA, on children's neurodevelopment. This study first examined the associations between multiple ELA categories (i.e., interpersonal threat, socioeconomic threat, interpersonal unpredictability, socioeconomic unpredictability, interpersonal deprivation, and socioeconomic deprivation) and the developmental changes in resting-state functional connectivity (rsFC) of the frontolimbic and temporal-limbic circuits implicated in cognition and psychopathology, using data from the Adolescent Brain Cognitive Development (ABCD) study, which included four measurements from baseline (mean ± SD age, 119.13 ± 7.51 months; 2815 females) to 3-year follow-up (N = 5885). Controlling for concurrent ELA categories, interpersonal unpredictability and socioeconomic deprivation were associated with accelerated development of rsFC between CON/RTN-amygdala/hippocampus (Cingulo-opercular Network, Retrosplenial Temporal Network). Compared to girls, boys' corticolimbic circuits development was more sensitive to interpersonal threat. Changes in rsFC mediated the associations between interpersonal unpredictability/socioeconomic deprivation with decreased crystallized cognition, fluid cognition, and internalizing problems. Additionally, socioeconomic deprivation was associated with decreased crystallized cognition through interpersonal unpredictability and changes in rsFC between CON and bilateral amygdala/right hippocampus. This study emphasized interpersonal unpredictability and socioeconomic deprivation as key environmental factors affecting corticolimbic circuit development implicated in cognition and psychopathology. Stable family environments and enriched neighborhoods are crucial for supporting optimal neural and behavioral development in children and adolescents.
早期生活逆境（ELA）极为普遍，对儿童的大脑发育和行为结果具有显著的有害影响。然而，在ELA的维度模型中，威胁、不可预测性和剥夺与皮质边缘回路之间的关联尚不清楚。先前的研究强调了亲近程度的影响，尤其是人际ELA和社会经济ELA之间的区别，对儿童神经发育的影响。本研究首次使用青少年大脑认知发展（ABCD）研究的数据，检验了多种ELA类别（即人际威胁、社会经济威胁、人际不可预测性、社会经济不可预测性、人际剥夺和社会经济剥夺）与涉及认知和精神病理学的额边缘和颞边缘回路静息态功能连接（rsFC）的发育变化之间的关联，该研究包括从基线（平均±标准差年龄，119.13±7.51个月；2815名女性）到3年随访（N = 5885）的四次测量。在控制同时存在的ELA类别后，人际不可预测性和社会经济剥夺与CON/RTN-杏仁核/海马体（扣带- opercular网络、 retrosplenial颞叶网络）之间的rsFC加速发展相关。与女孩相比，男孩的皮质边缘回路发育对人际威胁更敏感。rsFC的变化介导了人际不可预测性/社会经济剥夺与晶体认知、流体认知和内化问题减少之间的关联。此外，社会经济剥夺通过人际不可预测性以及CON与双侧杏仁核/右侧海马体之间的rsFC变化与晶体认知下降相关。本研究强调人际不可预测性和社会经济剥夺是影响涉及认知和精神病理学的皮质边缘回路发育的关键环境因素。稳定的家庭环境和丰富的社区对支持儿童和青少年的最佳神经和行为发育至关重要。
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