早期预后良好型霍奇金淋巴瘤中基线代谢肿瘤体积的预测价值 - 来自前瞻性、多中心 III 期 HD16 试验的数据。
Predictive value of baseline metabolic tumor volume in early-stage favorable Hodgkin Lymphoma - Data from the prospective, multicenter phase III HD16 trial.
机构信息
Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany.
First Department of Internal Medicine and German Hodgkin Study Group (GHSG), Center for Integrated Oncology Aachen - Bonn - Cologne - Düsseldorf (CIO ABCD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
出版信息
BMC Cancer. 2022 Jun 18;22(1):672. doi: 10.1186/s12885-022-09758-z.
BACKGROUND
F -fluorodeoxyglucose (FDG) positron emission tomography (PET) plays an important role in the staging and response assessment of lymphoma patients. Our aim was to explore the predictive relevance of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in patients with early stage Hodgkin lymphoma treated within the German Hodgkin Study Group HD16 trial.
METHODS
F-FDG PET/CT images were available for MTV and TLG analysis in 107 cases from the HD16 trial. We calculated MTV and TLG using three different threshold methods (SUV SUV and SUV), and then performed receiver-operating-characteristic analysis to assess the predictive impact of these parameters in predicting an adequate therapy response with PET negativity after 2 cycles of chemotherapy.
RESULTS
All three threshold methods analyzed for MTV and TLG calculation showed a positive correlation with the PET response after 2 cycles chemotherapy. The largest area under the curve (AUC) was observed using the fixed threshold of SUV for MTV- calculation (AUC 0.69 [95% CI 0.55-0.83]) and for TLG-calculation (AUC 0.69 [0.55-0.82]). The calculations for MTV and TLG with a relative threshold showed a lower AUC: using SUV AUCs of 0.66 [0.53-0.80] for MTV and 0.67 for TLG [0.54-0.81]) were observed, while with SUV an AUC of 0.61 [0.45-0.76] for MTV, and an AUC 0.64 [0.49-0.80]) for TLG were seen.
CONCLUSIONS
MTV and TLG do have a predictive value after two cycles ABVD in early stage Hodgkin lymphoma, particularly when using the fixed threshold of SUV for MTV and TLG calculation.
TRIAL REGISTRATION
ClinicalTrials.gov NCT00736320 .
背景
氟代脱氧葡萄糖（FDG）正电子发射断层扫描（PET）在淋巴瘤患者的分期和反应评估中发挥着重要作用。我们的目的是探索代谢肿瘤体积（MTV）和总病变糖酵解（TLG）在德国霍奇金研究组 HD16 试验中接受早期霍奇金淋巴瘤治疗的患者中的预测相关性。
方法
来自 HD16 试验的 107 例患者的 F-FDG PET/CT 图像可用于 MTV 和 TLG 分析。我们使用三种不同的阈值方法（SUV、SUV 和 SUV）计算 MTV 和 TLG，然后进行接受者操作特征分析，以评估这些参数在预测 2 个周期化疗后 PET 阴性时的充分治疗反应中的预测影响。
结果
三种用于 MTV 和 TLG 计算的阈值方法均与 2 个周期化疗后的 PET 反应呈正相关。使用 MTV 计算的固定 SUV 阈值（AUC 0.69 [95%CI 0.55-0.83]）和 TLG 计算的固定 SUV 阈值（AUC 0.69 [0.55-0.82]）观察到最大的曲线下面积（AUC）。使用相对阈值进行 MTV 和 TLG 计算的 AUC 较低：观察到 MTV 的 SUV AUC 为 0.66 [0.53-0.80]，TLG 的 AUC 为 0.67 [0.54-0.81]），而使用 SUV，MTV 的 AUC 为 0.61 [0.45-0.76]，TLG 的 AUC 为 0.64 [0.49-0.80]）。
结论
在早期霍奇金淋巴瘤中，ABVD 治疗 2 个周期后，MTV 和 TLG 具有预测价值，特别是当使用 MTV 和 TLG 计算的固定 SUV 阈值时。
试验注册
ClinicalTrials.gov NCT00736320 。
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