基线代谢肿瘤体积（MTV）对早期预后不良霍奇金淋巴瘤化疗疗效预测的预后价值：来自 III 期 HD17 试验的数据。

Prognostic value of baseline metabolic tumor volume (MTV) for forecasting chemotherapy outcome in early-stage unfavorable Hodgkin lymphoma: Data from the phase III HD17 trial.

机构信息

Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

First Department of Internal Medicine and German Hodgkin Study Group (GHSG), Center for Integrated Oncology Aachen-Bonn-Cologne-Düsseldorf (CIO ABCD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

出版信息

Eur J Haematol. 2023 Dec;111(6):881-887. doi: 10.1111/ejh.14093. Epub 2023 Aug 29.

DOI:10.1111/ejh.14093

PMID:37644732

Abstract

OBJECTIVES

The prognostic relevance of metabolic tumor volume (MTV) having recently been demonstrated in patients with early-stage favorable and advanced-stage Hodgkin lymphoma. The current study aimed to assess the potential prognostic value of F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in early-stage unfavorable Hodgkin lymphoma patients treated within the German Hodgkin Study Group HD17 trial.

METHODS

F-FDG PET/CT images were available for MTV analysis in 154 cases. We used three different threshold methods (SUV , SUV , and SUV ) to calculate MTV. Receiver-operating-characteristic analysis was performed to describe the value of these parameters in predicting an adequate therapy response. Therapy response was evaluated as PET negativity after 2 cycles of eBEACOPP followed by 2 cycles of ABVD.

RESULTS

All three threshold methods analyzed for MTV showed a positive correlation with the PET response after chemotherapy. Areas under the curve (AUC) were 0.70 (95% CI 0.53-0.87) and 0.65 (0.50-0.80) using the fixed thresholds of SUV and SUV , respectively, for MTV- calculation. The calculation of MTV using a relative threshold of SUV showed an AUC of 0.63 (0.47-0.79).

CONCLUSIONS

MTV does have predictive value after chemotherapy in early-stage unfavorable Hodgkin lymphoma, particularly when the fixed threshold of SUV is used for MTV calculation.

TRIAL REGISTRATION

ClinicalTrials.gov NCT01356680.

摘要

目的

代谢肿瘤体积（MTV）在早期预后良好和晚期霍奇金淋巴瘤患者中的预后相关性最近已经得到证实。本研究旨在评估 F-氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）在德国霍奇金研究组 HD17 试验中治疗的早期预后不良霍奇金淋巴瘤患者中的潜在预后价值。

方法

154 例患者的 F-FDG PET/CT 图像可用于 MTV 分析。我们使用三种不同的阈值方法（SUVmax、SUVmean 和 SUVpeak）来计算 MTV。采用受试者工作特征曲线分析描述这些参数预测充分治疗反应的价值。治疗反应评估为 2 个周期 eBEACOPP 后和 2 个周期 ABVD 后 PET 阴性。

结果

用于 MTV 分析的三种阈值方法均与化疗后 PET 反应呈正相关。使用 SUV 和 SUV 的固定阈值分别计算 MTV 时，曲线下面积（AUC）分别为 0.70（95%置信区间 0.53-0.87）和 0.65（0.50-0.80）。使用 SUV 的相对阈值计算 MTV 时，AUC 为 0.63（0.47-0.79）。