Peregud D I, Korolkov A I, Baronets V Y, Lobacheva A S, Arkus M L, Igumnov S A, Pirozhkov S V, Terebilina N N
Serbsky National Medical Research Center for Psychiatry and Drug Addiction, Moscow, Russia.
I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Biomed Khim. 2022 Jun;68(3):218-227. doi: 10.18097/PBMC20226803218.
Some BDNF (brain-derived neurotrophic factor)-targeted microRNAs such as miR-30a-5p associate with alcohol dependence phenomenon however their relationship with AWS is not described. We aimed to measure serum BDNF concentration and relative content of miR-30a-5p over the course of alcohol abstinence and compare obtained results with clinics of AWS. Additionally, we studied relative serum content of miR-30a-5p, a microRNA which does not target BDNF but relates to alcohol use disorder. Serum BDNF concentration increased over the course of alcohol abstinence, contrary relative content of miR-122 but not miR-30a-5p decreased. Moreover, during AWS miR-122 but miR-30a-5p negatively correlated with serum BDNF concentrations. Relative content of miR-122 negatively correlated with depression and state anxiety levels on 8th day of abstinence. According to multiple regressions on 21st day of abstinence alcohol craving and cognitive disturbances may be predictors of serum BDNF concentration, and vice versa. Thus, serum BDNF concentration and relative content of miR-122 associate with some aspects of AWS clinics and may dynamically reflect AWS severity.
一些靶向脑源性神经营养因子（BDNF）的微小RNA，如miR-30a-5p，与酒精依赖现象相关，然而它们与酒精戒断综合征（AWS）的关系尚未见描述。我们旨在测定戒酒过程中血清BDNF浓度及miR-30a-5p的相对含量，并将所得结果与AWS临床症状进行比较。此外，我们研究了不靶向BDNF但与酒精使用障碍相关的微小RNA miR-30a-5p的血清相对含量。戒酒过程中血清BDNF浓度升高，相反，miR-122的相对含量降低，但miR-30a-5p未降低。此外，在AWS期间，miR-122与血清BDNF浓度呈负相关，但miR-30a-5p并非如此。在戒酒第8天，miR-122的相对含量与抑郁和状态焦虑水平呈负相关。根据戒酒第21天的多元回归分析，酒精渴望和认知障碍可能是血清BDNF浓度的预测因素，反之亦然。因此，血清BDNF浓度和miR-122的相对含量与AWS临床症状的某些方面相关，可能动态反映AWS的严重程度。
