BDNF CpG 甲基化与酒精使用障碍患者戒断期间血清水平的相关性：一项初步研究。
BDNF CpG methylation and serum levels covary during alcohol withdrawal in patients with alcohol use disorder: A pilot study.
机构信息
Unité de Recherche et d'Innovation, Fédération de la recherche et de l'innovation, Centre Hospitalier Esquirol, Limoges, France.
Inserm U1094, IRD U270, Univ. Limoges, CHU Limoges, EpiMaCT - Epidemiology of Chronic Diseases in Tropical Zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France.
出版信息
World J Biol Psychiatry. 2023 Nov;24(9):854-859. doi: 10.1080/15622975.2023.2242924. Epub 2023 Aug 9.
OBJECTIVES
Brain-derived neurotrophic factor (BDNF) levels vary in various conditions including alcohol use disorder (AUD). We aimed to identify drivers of these variations.
METHODS
Twelve patients with AUD were assessed at hospitalisation for alcohol withdrawal and four months later. We looked for associations between the change in serum BDNF levels and (1) length of abstinence, (2) anxiety (Hamilton Anxiety Scale) and depression (Beck-Depression Inventory), (3) one functional BDNF genotype (rs6265) and (4) methylation levels of 12 CpG sites within the BDNF gene (located in exons I, IV and IX).
RESULTS
While abstinence remained, serum BDNF level increased. This increase correlated with the variation of methylation levels of the gene, and more specifically of exon I. We found no significant effect of length of abstinence, rs6265, depression or anxiety on serum BDNF level.
CONCLUSIONS
Epigenetic regulation of the gene may be involved in variations of BDNF blood level associated with alcohol abstinence.
目的
脑源性神经营养因子（BDNF）水平在包括酒精使用障碍（AUD）在内的各种情况下存在差异。我们旨在确定这些变化的驱动因素。
方法
12 名 AUD 患者在住院戒酒时和四个月后进行评估。我们研究了血清 BDNF 水平变化与（1）戒断时间、（2）焦虑（汉密尔顿焦虑量表）和抑郁（贝克抑郁量表）、（3）一种功能性 BDNF 基因型（rs6265）和（4）BDNF 基因内的 12 个 CpG 位点的甲基化水平（位于外显子 I、IV 和 IX）之间的关系。
结果
在戒断期间，血清 BDNF 水平增加。这种增加与基因的甲基化水平的变化相关，更具体地与外显子 I 的变化相关。我们没有发现戒断时间、rs6265、抑郁或焦虑对血清 BDNF 水平有显著影响。
结论
基因的表观遗传调控可能参与了与酒精戒断相关的 BDNF 血液水平的变化。
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