老年大鼠神经滋养血管的去甲肾上腺素能神经支配：一项荧光组织化学研究。

The noradrenergic innervation of the vasa nervorum in old rats: a fluorescence histochemical study.

作者信息

Mione M C, Cavallotti C, Collier W L, Amenta F

出版信息

J Auton Nerv Syst. 1987 Feb;18(2):177-80. doi: 10.1016/0165-1838(87)90104-4.

Abstract

The effect of ageing on the density and pattern of noradrenergic nerves in the perivascular nerve plexus supplying the vasa nervorum of the rat sciatic nerve was studied using combined catecholamine histofluorescence and quantitative image analysis techniques. The density of noradrenergic fibres around arteries and arterioles of the rat sciatic nerve vasa nervorum increased in the old animals. In contrast, no changes in perivascular nerve fibres supplying the veins and venules were found in the vasa nervorum of old rats. The increase in old age of noradrenergic innervation of arteries and arterioles of the vasa nervorum may be related to the pathogenesis of some peripheral nerve diseases.

摘要

采用儿茶酚胺组织荧光与定量图像分析技术相结合的方法，研究了衰老对大鼠坐骨神经血管神经丛中去甲肾上腺素能神经密度和分布模式的影响。老年大鼠坐骨神经血管神经丛的动脉和小动脉周围去甲肾上腺素能纤维密度增加。相比之下，老年大鼠血管神经丛中供应静脉和小静脉的血管周围神经纤维未发现变化。血管神经丛中动脉和小动脉去甲肾上腺素能神经支配的老年增加可能与某些周围神经疾病的发病机制有关。