Renal Division, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.
Renal Division, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.
Semin Nephrol. 2022 Mar;42(2):208-218. doi: 10.1016/j.semnephrol.2022.04.010.
Female sex confers renoprotection in chronic progressive kidney disease. It is less well recognized that sexual dimorphism also is evident in the development of ischemic and nephrotoxic acute kidney injury (AKI). Animal studies consistently have shown that female sex protects against the development of renal injury in experimental models of ischemic AKI. However, the consensus opinion is that in human beings, female sex is an independent risk factor for AKI. Based on a systematic review of experimental and clinical literature, we present data to support the conclusion that, contrary to consensus opinion, it is male sex, not female sex, that is associated with the development of AKI.
女性性别赋予慢性进行性肾脏疾病的肾脏保护作用。但人们较少认识到，在缺血性和肾毒性急性肾损伤 (AKI) 的发展中也存在性别二态性。动物研究一致表明，女性性别可预防缺血性 AKI 实验模型中肾脏损伤的发展。然而，共识意见认为，在人类中，女性性别是 AKI 的独立危险因素。基于对实验和临床文献的系统回顾，我们提供的数据支持以下结论：与共识意见相反，与 AKI 发展相关的是男性性别，而不是女性性别。
