Agha F P, Keren D F
J Clin Gastroenterol. 1987 Apr;9(2):232-7.
Of 70 patients with achalasia and related motor disorders, 3 developed Barrett's esophagus 5, 8, and 15 years after esophagomyotomy. One of the three had dysplastic changes in the Barrett's mucosa. Although an increased incidence of gastroesophageal reflux, esophagitis, and stricture are well-known complications after esophagomyotomy, the development of Barrett's mucosa has been only recently recognized. Diagnosis of Barrett's esophagus in such patients is difficult and requires a high index of awareness by the radiologist and an endoscopic biopsy for definitive diagnosis. The cumulative effects of achalasia and Barrett's esophagus predispose these patients to higher risks of developing esophageal carcinoma.
在70例贲门失弛缓症及相关运动障碍患者中,3例在食管肌层切开术后5年、8年和15年发生了巴雷特食管。这3例患者中有1例巴雷特黏膜出现发育异常改变。尽管食管肌层切开术后胃食管反流、食管炎和狭窄的发生率增加是众所周知的并发症,但巴雷特黏膜的发生直到最近才被认识到。在此类患者中诊断巴雷特食管很困难,需要放射科医生高度警惕,并通过内镜活检进行确诊。贲门失弛缓症和巴雷特食管的累积效应使这些患者发生食管癌的风险更高。