Brunkard Jacob O, Chang Caren, Mayer Bruce J, Meyer Christian, Sheen Jen
University of Wisconsin, Madison.
University of Maryland, College Park.
Fac Rev. 2022 May 10;11:12. doi: 10.12703/r-01-000008. eCollection 2022.
Development is coordinated by dozens of signals that act in overlapping pathways to orchestrate multicellular growth. Understanding how signaling pathways intersect and diverge at a molecular level is critical to predicting how organisms will react to dynamic environmental conditions. In plants, two antagonistic signaling hubs are strictly required to sense and respond to many nutrients and hormones: TARGET OF RAPAMYCIN (TOR) and ETHYLENE INSENSITIVE 2 (EIN2). In this Landmark report, Fu discover that TOR and EIN2 directly interact to choreograph growth and define an unexpected molecular mechanism at the intersection of hormonal and metabolic signaling networks.
发育由数十种信号协调，这些信号在重叠的通路中发挥作用，以精心安排多细胞生长。了解信号通路在分子水平上如何交叉和分叉对于预测生物体如何应对动态环境条件至关重要。在植物中，严格需要两个相互拮抗的信号枢纽来感知和响应许多营养物质和激素：雷帕霉素靶蛋白（TOR）和乙烯不敏感2（EIN2）。在这份具有里程碑意义的报告中，傅发现TOR和EIN2直接相互作用，以编排生长并在激素和代谢信号网络的交叉点定义了一种意想不到的分子机制。
