抗HD IgM作为慢性丁型肝炎感染的标志物。

Anti-HD IgM as a marker of chronic delta infection.

作者信息

Buti M, Esteban R, Esteban J I, Allende H, Jardi R, Guardia J

出版信息

J Hepatol. 1987 Feb;4(1):62-5. doi: 10.1016/s0168-8278(87)80010-7.

PMID:3571933

Abstract

The value of anti-HD IgM as a marker of chronic delta infection was evaluated by correlating its presence in serum with that of HD-Ag in liver cells and with the degree of inflammatory activity. Thirty-six patients with HBsAg-positive chronic hepatitis and anti-HD at high titers were studied. Overall, the liver cells of 26 patients contained HD-Ag and 27 were positive for IgM anti-HD. The correlation between both markers was excellent: 25 cases were positive for both serum anti-HD IgM and intrahepatic HD-Ag and 8 were negative for both markers. There was only 1 HD-Ag-positive patient, who was anti-HD IgM-negative. Two patients were anti-HD IgM-positive and HD-Ag-negative. Histological damage was more severe in anti-HD IgM-positive cases than in those negative for this marker (Knodell's index 13.5 vs 11.9, P less than 0.01). We conclude that anti-HD IgM is a good marker of chronic active delta infection.

摘要

通过将血清中抗HD IgM的存在与肝细胞中HD-Ag的存在以及炎症活动程度相关联，评估了抗HD IgM作为慢性丁型肝炎感染标志物的价值。对36例HBsAg阳性、抗HD高滴度的慢性肝炎患者进行了研究。总体而言，26例患者的肝细胞含有HD-Ag，27例抗HD IgM呈阳性。两种标志物之间的相关性极佳：25例血清抗HD IgM和肝内HD-Ag均为阳性，8例两种标志物均为阴性。仅有1例HD-Ag阳性患者抗HD IgM阴性。2例患者抗HD IgM阳性但HD-Ag阴性。抗HD IgM阳性病例的组织学损伤比该标志物阴性的病例更严重（Knodell指数分别为13.5和11.9，P<0.01）。我们得出结论，抗HD IgM是慢性活动性丁型肝炎感染的良好标志物。