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不同 COVID-19 接种间隔的患者在伤口愈合和瘢痕形成方面无差异。

No Differences in Wound Healing and Scar Formation Were Observed in Patients With Different COVID-19 Vaccination Intervals.

机构信息

Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

出版信息

Front Public Health. 2022 Jun 1;10:883113. doi: 10.3389/fpubh.2022.883113. eCollection 2022.

Abstract

BACKGROUND

Safety concerns are one of the most common reasons for COVID-19 vaccination refusal. In the field of plastic and reconstructive surgery, whether COVID-19 vaccination influences wound healing and scar formation is worthy of special attention.

METHODS

In this study, patients with adult trauma with subcutaneous sutures placed by a single plastic surgeon in a single center were included. The vaccination interval was defined as the interval between the last dose of the COVID-19 vaccine and when surgical sutures were introduced. The patients were categorized by vaccination interval into three groups of <1, 1-3, and ≥3 months. Wound healing and scar formation were rated according to the Wound Assessment Inventory (WAI) and Patient and Observer Scar Assessment Scale (POSAS) in the groups at 7 days and after a 3-month follow-up.

RESULTS

All total and individual scores of WAI and POSAS were not significantly different among the groups.

CONCLUSION

No differences in wound healing and scar formation were observed in patients with different COVID-19 vaccination intervals. Thus, it is not necessary to postpone COVID-19 vaccination, as the vaccine does not affect wound healing and scar formation in patients undergoing surgery. This study aimed to eliminate concerns and hesitancy in receiving the COVID-19 vaccine.

摘要

背景

安全性顾虑是 COVID-19 疫苗接种拒绝的最常见原因之一。在整形外科学领域,COVID-19 疫苗接种是否影响伤口愈合和瘢痕形成值得特别关注。

方法

本研究纳入了在单中心由同一位整形医生进行皮下缝合的成年创伤患者。接种间隔定义为 COVID-19 疫苗最后一剂与引入手术缝线之间的时间间隔。根据接种间隔将患者分为<1、1-3 和≥3 个月三组。在 7 天和 3 个月随访时,使用伤口评估量表(WAI)和患者与观察者瘢痕评估量表(POSAS)对各组的伤口愈合和瘢痕形成进行评分。

结果

WAI 和 POSAS 的总分和各单项评分在各组之间均无显著差异。

结论

不同 COVID-19 接种间隔的患者的伤口愈合和瘢痕形成无差异。因此,无需推迟 COVID-19 疫苗接种,因为疫苗不会影响手术患者的伤口愈合和瘢痕形成。本研究旨在消除对接受 COVID-19 疫苗的担忧和犹豫。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4591/9198238/b1c9988ad43d/fpubh-10-883113-g0001.jpg

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