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比较钛涂层缝线材料和非涂层缝线材料在重建手术皮瓣供区的瘢痕质量。

Scar quality examination comparing titanium-coated suture material and non-coated suture material on flap donor sites in reconstructive surgery.

机构信息

Department of Orthopedic, Trauma and Plastic Surgery, Leipzig University Hospital, Liebigstraße 20, 04103, Leipzig, Saxony, Germany.

出版信息

BMC Surg. 2020 Nov 3;20(1):268. doi: 10.1186/s12893-020-00932-3.

Abstract

BACKGROUND

Wound healing and scar quality after trauma are subject to impairment through excessive wound healing, chronic wound or even surgical site infections. Optimizing the process of scar formation and skin healing is crucial in virtually all fields of medicine. In this regard, we tested the possible usage and advantages of titanium coated suture material.

METHODS

We performed a prospective observational cohort study including 30 patients who underwent soft tissue reconstruction. One half of the donor flap site was sutured with titanium coated suture material, while the other half was closed with non-coated sutures. Scar quality of the donor flap site was assessed by photographs and POSAS scores on days 2-5, 14, 42, 72 and 180 postoperatively.

RESULTS

No difference between the titanium coated sutures and non-coated sutures was seen in the POSAS assessment, neither for the patient scale at 14, 42, 72 and 180 days, nor for the observer scale on the same dates. Comorbidities like diabetes, chronic renal failure and smoking as well as the BMI of each patient affected the wound healing process to an equal degree on both sides of the suture.

CONCLUSIONS

No difference between the titanium coated and non-titanium-coated suture material was seen in the POSAS assessment in regard to scar quality and wound healing. The titanium-coated suture material can be considered to be equally as effective and safe in all qualities as the non-titanium-coated suture material, even in patients with comorbidities. Clinical trial register This study is registered at the German Clinical Trials Register (DRKS) under the registration number DRKS00021767. ( https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00021767 ).

摘要

背景

创伤后伤口愈合和瘢痕质量会因过度愈合、慢性伤口甚至手术部位感染而受损。优化瘢痕形成和皮肤愈合过程在几乎所有医学领域都至关重要。在这方面,我们测试了钛涂层缝线材料的可能用途和优势。

方法

我们进行了一项前瞻性观察队列研究,纳入了 30 名接受软组织重建的患者。供区皮瓣的一半用钛涂层缝线缝合,另一半用非涂层缝线缝合。术后第 2-5、14、42、72 和 180 天通过照片和 POSAS 评分评估供区皮瓣部位的瘢痕质量。

结果

在 POSAS 评估中,钛涂层缝线和非涂层缝线之间在患者评分、观察者评分方面均无差异,在术后第 14、42、72 和 180 天。每位患者的合并症(如糖尿病、慢性肾衰竭和吸烟)和 BMI 同样影响缝线两侧的伤口愈合过程。

结论

在 POSAS 评估中,钛涂层缝线和非钛涂层缝线在瘢痕质量和伤口愈合方面无差异。钛涂层缝线材料在所有质量方面都与非钛涂层缝线材料同样有效和安全,即使在合并症患者中也是如此。

临床试验注册号

本研究在德国临床试验注册中心(DRKS)注册,注册号为 DRKS00021767。(https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00021767)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d70/7640681/997c05de1aee/12893_2020_932_Fig1_HTML.jpg

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