Zhou Xiaoxi, Fu Yadong, Liu Wei, Mu Yongping, Zhang Hua, Chen Jiamei, Liu Ping
Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai, China.
Front Mol Biosci. 2022 Jun 3;9:928321. doi: 10.3389/fmolb.2022.928321. eCollection 2022.
Ferroptosis, an iron-dependent non-apoptotic cell death characterized by lipid peroxidation, is a cell death pathway discovered in recent years. Ferroptosis plays an important role in tumors, ischemia-reperfusion injury, neurological diseases, blood diseases, etc. Recent studies have shown the importance of ferroptosis in chronic liver disease. This article summarizes the pathological mechanisms of ferroptosis involved in System Xc-, iron metabolism, lipid metabolism, and some GPX4-independent pathways, and the latest research on ferroptosis in chronic liver diseases such as alcoholic liver disease, non-alcoholic fatty liver disease, liver fibrosis, hepatocellular carcinoma. In addition, the current bottleneck issues that restrict the research on ferroptosis are proposed to provide ideas and strategies for exploring new therapeutic targets for chronic liver diseases.
铁死亡是一种以脂质过氧化为特征的铁依赖性非凋亡性细胞死亡，是近年来发现的一种细胞死亡途径。铁死亡在肿瘤、缺血再灌注损伤、神经疾病、血液疾病等方面发挥着重要作用。最近的研究表明铁死亡在慢性肝病中具有重要意义。本文总结了铁死亡在胱氨酸/谷氨酸反向转运体系统（System Xc-）、铁代谢、脂质代谢以及一些不依赖谷胱甘肽过氧化物酶4（GPX4）的途径中涉及的病理机制，以及铁死亡在酒精性肝病、非酒精性脂肪性肝病、肝纤维化、肝细胞癌等慢性肝病中的最新研究。此外，还提出了目前限制铁死亡研究的瓶颈问题，为探索慢性肝病新的治疗靶点提供思路和策略。
