Li Lanqing, Wang Xiaoqiang, Xu Haiying, Liu Xianqiong, Xu Kang
Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Hubei Engineering Technology Research Center of Chinese Materia Medica Processing, College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.
Front Mol Biosci. 2022 Aug 16;9:947208. doi: 10.3389/fmolb.2022.947208. eCollection 2022.
Ferroptosis is a novel process of regulated cell death discovered in recent years, mainly caused by intracellular lipid peroxidation. It is morphologically manifested as shrinking of mitochondria, swelling of cytoplasm and organelles, rupture of plasma membrane, and formation of double-membrane vesicles. Work done in the past 5 years indicates that induction of ferroptosis is a promising strategy in the treatment of hepatocellular carcinoma (HCC). , iron metabolism, p53 and lipid peroxidation pathways are the main focus areas in ferroptosis research. In this paper, we analyze the ferroptosis-inducing drugs and experimental agents that have been used in the last 5 years in the treatment of HCC. We summarize four different key molecular mechanisms that induce ferroptosis, i.e., , iron metabolism, p53 and lipid peroxidation. Finally, we outline the prognostic analysis associated with ferroptosis in HCC. The findings summarized suggest that ferroptosis induction can serve as a promising new therapeutic approach for HCC and can provide a basis for clinical diagnosis and prevention of this disease.
铁死亡是近年来发现的一种新型程序性细胞死亡过程，主要由细胞内脂质过氧化引起。其形态学表现为线粒体缩小、细胞质和细胞器肿胀、质膜破裂以及双膜小泡形成。过去5年的研究表明，诱导铁死亡是治疗肝细胞癌（HCC）的一种有前景的策略。铁代谢、p53和脂质过氧化途径是铁死亡研究的主要重点领域。在本文中，我们分析了过去5年用于治疗HCC的铁死亡诱导药物和实验试剂。我们总结了诱导铁死亡的四种不同关键分子机制，即铁代谢、p53和脂质过氧化。最后，我们概述了与HCC中铁死亡相关的预后分析。总结的研究结果表明，诱导铁死亡可作为一种有前景的HCC新治疗方法，并可为该疾病的临床诊断和预防提供依据。
