Elsahoryi Nour A, Cardwell Christopher, Gilchrist Sarah, Woodside Jayne V
Centre for Public Health, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, UK.
Department of Nutrition, Faculty of Pharmacy & Medical Sciences, University of Petra, Amman, Jordan.
J Nutr Sci. 2022 Jun 6;11:e41. doi: 10.1017/jns.2022.34. eCollection 2022.
Beetroot juice (BRJ) has been demonstrated to decrease blood pressure (BP) due to the high inorganic nitrate content. This pilot randomized crossover trial aimed to investigate the effect of two different high nitrate vegetable juices on plasma nitrate concentrations and BP in healthy adults. Eighteen healthy volunteers were randomized to receive 115 ml of BRJ or 250 ml of green leafy vegetable juice for 7 d which contained similar amounts of nitrate (340 mg) daily. Blood samples were collected, and clinic BP measured at baseline and at the end of each juice consumption. Daily home BP assessment was conducted 2 h after juice consumption. Nitrate and nitrite concentrations were analysed using a commercially available kit on a Triturus automated ELISA analyser. Hills and Armitage analysis was used for the two-period crossover design and paired sample -tests were performed to compare within-group changes. Plasma nitrate and nitrite concentrations significantly increased and there was a significant reduction in clinic and home systolic blood pressure (SBP) mean during the BRJ period (-values 0⋅004 and 0⋅002, respectively). Home diastolic blood pressure (DBP) reduced significantly during green leafy vegetable juice consumption week (-value 0⋅03). The difference between groups did not reach statistical significance during the formal crossover analysis adjusted for period effects. BRJ and green leafy vegetable juice may reduce SBP or DBP, but there was no statistically significant difference between the two juices, although this was only a pilot study.
甜菜根汁（BRJ）已被证明由于其高无机硝酸盐含量可降低血压（BP）。这项初步随机交叉试验旨在研究两种不同的高硝酸盐蔬菜汁对健康成年人血浆硝酸盐浓度和血压的影响。18名健康志愿者被随机分配，连续7天每天饮用115毫升甜菜根汁或250毫升绿叶蔬菜汁，两种汁液每天所含硝酸盐量相似（340毫克）。在基线期以及每种汁液饮用结束时采集血样并测量临床血压。在饮用汁液2小时后进行每日家庭血压评估。使用市售试剂盒在Triturus自动酶联免疫吸附测定分析仪上分析硝酸盐和亚硝酸盐浓度。对于两期交叉设计采用希尔斯和阿米蒂奇分析，并进行配对样本检验以比较组内变化。在饮用甜菜根汁期间，血浆硝酸盐和亚硝酸盐浓度显著升高，临床和家庭收缩压（SBP）平均值显著降低（P值分别为0.004和0.002）。在饮用绿叶蔬菜汁的那一周，家庭舒张压（DBP）显著降低（P值为0.03）。在针对周期效应进行调整的正式交叉分析中，两组之间的差异未达到统计学显著性。甜菜根汁和绿叶蔬菜汁可能会降低收缩压或舒张压，但两种汁液之间没有统计学上的显著差异，不过这只是一项初步研究。
