Lopes Kaoue Fonseca, Bahia Valéria Santoro, Natividade Jean Carlos, Bastos Rafael Valdece Sousa, Shiguti Wanderley Akira, da Silva Kátia Estevão Rodrigues, de Souza Wânia Cristina
Universidade de Brasília, Instituto de Psicologia, Departamento de Processos Psicológicos Básicos, Brasília DF, Brazil.
Clínica de Neurologia Neurob, Brasília DF, Brazil.
Dement Neuropsychol. 2022 Apr-Jun;16(2):187-193. doi: 10.1590/1980-5764-DN-2021-0029. Epub 2022 Apr 29.
Changes in personality traits in patients with Alzheimer's disease (AD) are extremely common throughout the course of the pathology, and these behavioral changes present themselves as challenges in clinical management and as a significant cause of caregivers' burden.
Using a personality inventory based on the five-factor model of personality, this study aimed to assesses the change in these factors by comparing the premorbid and current personality of individuals recently diagnosed with AD.
A total of 30 AD patients were recruited, and their respective family members responded to the personality inventory at home through a hosted site. The patients were also divided into two groups according to the Clinical Dementia Rating (CDR): mild dementia (CDR 1) and moderate dementia (CDR 2).
Among all patients, there was a significant increase in neuroticism factor levels and a significant decrease in the extraversion, conscientiousness, openness, and socialization factors. When comparing the groups, only the extraversion factor showed a difference, with CDR 1 group accusing a higher change in scores. Higher scores in the factor neuroticism in the premorbid personality correlated with the current severity of the disease.
This research draws the attention of family members and health professionals to changes in personality traits or behavior of relatives or patients, because it can reflect an underlying neurodegenerative process.
阿尔茨海默病（AD）患者的人格特质变化在整个病程中极为常见，这些行为变化给临床管理带来挑战，也是护理人员负担的重要原因。
本研究使用基于人格五因素模型的人格量表，旨在通过比较近期诊断为AD的个体病前和当前的人格来评估这些因素的变化。
共招募了30名AD患者，他们各自的家庭成员通过一个托管网站在家中完成人格量表。患者还根据临床痴呆评定量表（CDR）分为两组：轻度痴呆（CDR 1）和中度痴呆（CDR 2）。
在所有患者中，神经质因子水平显著升高，外向性、尽责性、开放性和社交性因子显著降低。在比较两组时，只有外向性因子显示出差异，CDR 1组的得分变化更高。病前人格中神经质因子得分较高与当前疾病严重程度相关。
本研究提请家庭成员和健康专业人员关注亲属或患者人格特质或行为的变化，因为这可能反映潜在的神经退行性过程。
