Koo Taehan, Kang Hyun Ji, Kim Min-Soo, Jue Mihn-Sook
Department of Dermatology, Veterans Health Service Medical Center, Seoul, Korea.
Ann Dermatol. 2022 Jun;34(3):225-227. doi: 10.5021/ad.2022.34.3.225. Epub 2022 May 20.
Intralymphatic histiocytosis (ILH) is a rare cutaneous condition with uncertain pathogenesis. It is characterized by dilated lymphatic vessels that contain histiocytes within their lumina. Although the etiology of ILH remains unknown, it has been associated with various inflammatory and neoplastic diseases, such as rheumatoid arthritis (RA), reaction to metal joint implants and Merkel cell carcinoma, breast cancer and colon cancer. An 83-year-old female presented with an erythematous patch on the left forearm that had appeared six months previous. She had suffered from osteoarthritis (OA) and the cutaneous lesion was located in the vicinity of the affected joint. Skin biopsy from the lesion showed dilated dermal vessels and some ectatic vessels that contained many mononuclear histiocytes. Based on the clinical and histopathological findings, we diagnosed her with ILH with OA. Two sessions of intralesional triamcinolone acetonide injection (5 mg/ml) were administered to treat the skin lesion, which gradually improved over a period of a few months. We here report a rare case of ILH associated with degenerative OA.
淋巴管内组织细胞增多症（ILH）是一种发病机制不明的罕见皮肤病。其特征是淋巴管扩张，管腔内含有组织细胞。尽管ILH的病因尚不清楚，但它与多种炎症性和肿瘤性疾病有关，如类风湿关节炎（RA）、对金属关节植入物的反应以及默克尔细胞癌、乳腺癌和结肠癌。一名83岁女性，左前臂出现红斑，该红斑于6个月前出现。她患有骨关节炎（OA），皮肤病变位于受影响关节附近。病变部位的皮肤活检显示真皮血管扩张，一些扩张的血管内含有许多单核组织细胞。根据临床和组织病理学检查结果，我们诊断她为伴有OA的ILH。给予两次皮损内注射曲安奈德（5mg/ml）以治疗皮肤病变，病变在几个月内逐渐改善。我们在此报告一例与退行性OA相关的罕见ILH病例。
