Yang Li, Zhao Zhibin
Department of Gastroenterology, Taizhou People's Hospital, Taizhou 225300, China.
Evid Based Complement Alternat Med. 2022 Jun 9;2022:7223632. doi: 10.1155/2022/7223632. eCollection 2022.
To investigate the effect of somatostatin combined with ulinastatin in the treatment of patients with severe acute pancreatitis and its effect on serum cytokine levels.
This study is a retrospective trial. One hundred patients with severe acute pancreatitis in our hospital between March 2020 and May 2021 were recruited and assigned into the control group (ulinastatin alone) and experimental group (somatostatin plus ulinastatin) according to different treatment methods, 50 cases each. The clinical efficacy and serum cytokine levels of the two groups were compared.
Somatostatin plus ulinastatin was associated with a higher total effective rate versus ulinastatin alone ( < 0.05). After treatment, the experimental group observed significantly better interleukin-10 (IL-10), interleukin-18 (IL-18), and tumor necrosis factor- (TNF-) when compared with those in the control group ( < 0.05); somatostatin plus ulinastatin resulted in better serum amylase, blood calcium, blood urea nitrogen, blood sugar, and white blood cell count versus ulinastatin alone ( < 0.05).
Somatostatin plus ulinastatin is a viable alternative in the treatment of patients with severe acute pancreatitis, with a remarkable efficacy profile. It is worthy of clinical application.
探讨生长抑素联合乌司他丁治疗重症急性胰腺炎患者的效果及其对血清细胞因子水平的影响。
本研究为回顾性试验。选取2020年3月至2021年5月我院收治的100例重症急性胰腺炎患者，根据不同治疗方法分为对照组（单纯使用乌司他丁）和试验组（生长抑素加乌司他丁），每组50例。比较两组的临床疗效和血清细胞因子水平。
生长抑素加乌司他丁组的总有效率高于单纯使用乌司他丁组（<0.05）。治疗后，试验组的白细胞介素-10（IL-10）、白细胞介素-18（IL-18）和肿瘤坏死因子-（TNF-）水平明显优于对照组（<0.05）；生长抑素加乌司他丁组的血清淀粉酶、血钙、血尿素氮、血糖和白细胞计数较单纯使用乌司他丁组改善更明显（<0.05）。
生长抑素加乌司他丁是治疗重症急性胰腺炎患者的一种可行选择，疗效显著。值得临床应用。
