Cui Xuena, Ji Yuzhi, Zhang Lijuan, Lv Qiulan, Liu Ling
Department of Obstetrics, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, China.
Evid Based Complement Alternat Med. 2022 Jun 9;2022:1249779. doi: 10.1155/2022/1249779. eCollection 2022.
To investigate the effect of Baogong Zhixue granules combined with tranexamic acid injection on the hemodynamics and reproductive system in patients with postpartum hemorrhage (PPH) after cesarean section.
The data of 90 puerperae undergoing cesarean section in our hospital from January 2019 to January 2020 were retrospectively analyzed. According to the order of admission, they were equally divided into the control group (CG) and experimental group (EG). CG was treated with tranexamic acid injection combined with oxytocin, while EG was treated with Baogong Zhixue granules combined with tranexamic acid injection to compare the clinical observation indexes between the two groups.
Compared with CG, EG achieved remarkably less amount of bleeding at 2 h and 24 h after delivery ( < 0.001), lower postpartum APTT, PT, HR, and MAP ( < 0.001), shorter maintenance time of uterine contraction and lochia ( < 0.001), and lower postpartum FSH and LH ( < 0.001). After delivery, EG had higher postpartum Fib and descending speed of uterine fundus and compared with CG ( < 0.001).
Baogong Zhixue granules combined with tranexamic acid injection have little effect on the reproductive system of PPH patients after cesarean section, stabilize the hemodynamics, and improve the coagulation function. Therefore, further research on the combined treatment can provide better hemostatic schemes for such patients.
探讨包公止血颗粒联合氨甲环酸注射液对剖宫产术后产后出血（PPH）患者血流动力学及生殖系统的影响。
回顾性分析2019年1月至2020年1月在我院行剖宫产的90例产妇资料。按入院顺序将其分为对照组（CG）和实验组（EG）。CG采用氨甲环酸注射液联合缩宫素治疗，EG采用包公止血颗粒联合氨甲环酸注射液治疗，比较两组的临床观察指标。
与CG相比，EG产后2小时和24小时出血量明显减少（<0.001），产后APTT、PT、HR和MAP较低（<0.001），子宫收缩和恶露持续时间较短（<0.001），产后FSH和LH较低（<0.001）。产后，EG的产后纤维蛋白原水平较高，子宫底下降速度较快，与CG相比差异有统计学意义（<0.001）。
包公止血颗粒联合氨甲环酸注射液对剖宫产术后PPH患者生殖系统影响较小，能稳定血流动力学，改善凝血功能。因此，对该联合治疗进行进一步研究可为这类患者提供更好的止血方案。
