Adewole Adebayo A, Onile Temitope G, Ugiagbe Austin O, Fadahunsi Oluwaseyi O, Awelimobor Daniel I, Akinro Omotayo
Department of Obstetrics and Gynecology, Federal Medical Center, Lokoja, Nigeria.
Department of Histopathology and Morbid Anatomy, Federal Medical Center, Lokoja, Nigeria.
J Taibah Univ Med Sci. 2021 Nov 14;17(3):523-528. doi: 10.1016/j.jtumed.2021.10.007. eCollection 2022 Jun.
Sarcomas arising from the cervix are rare, and the reported prevalence is 0.20-0.55%. A 15-year-old Para 0 secondary school student presented to the emergency department in shock with a 1-year history of painless vaginal protrusion, vaginal bleeding, foul-smelling vaginal discharge, occasional passage of blood clots, fatigue, fainting episodes, and weight loss. She was resuscitated with intravenous fluids and blood transfusions. General examination revealed a young girl with a 16-week sized abdominal mass. Vaginal examination revealed a large mobile fleshy mass 14 cm by 10 cm with an offensive discharge and odour. It was externally friable, bled actively on contact, had areas of tissue necrosis, and was oedematous. It was difficult to determine the adnexa structures because of tenderness. Examination under anaesthesia showed that the mass was continuous with the cervix and was not attached to the vagina or vulva. The histology report of the biopsied specimens showed features consistent with cervical leiomyosarcoma (LMS). Cervical LMS was confirmed by immunohistochemistry and a total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed as definitive treatment. Postoperative hormone replacement therapy was initiated. The patient's postoperative condition was stable and there was no tumour recurrence for >2 years on follow-up. Making a diagnosis and instituting surgical and adjuvant treatments for LMS in a low-resource setting are challenging. This is due to lack of access to universal healthcare coverage. A multidisciplinary approach with early diagnosis and complete surgical resection of the tumour provides the most favourable possibility of an improved survival and quality of life.
宫颈肉瘤较为罕见,报告的患病率为0.20 - 0.55%。一名15岁、未生育的中学生因无痛性阴道肿物突出、阴道出血、阴道分泌物有异味、偶尔排出血块、疲劳、昏厥发作及体重减轻等症状,休克状态下被送至急诊科。她接受了静脉输液和输血复苏治疗。全身检查发现一名年轻女孩腹部有一个16周大小的肿物。阴道检查发现一个14厘米×10厘米的可移动肉质大肿物,有脓性分泌物和异味。肿物表面脆弱,触诊时活动性出血,有组织坏死区域且水肿。由于触痛,难以确定附件结构。麻醉下检查显示肿物与宫颈相连,未附着于阴道或外阴。活检标本的组织学报告显示特征符合宫颈平滑肌肉瘤(LMS)。通过免疫组化确诊为宫颈LMS,并进行了全腹子宫切除术和双侧输卵管卵巢切除术作为确定性治疗。术后开始了激素替代治疗。患者术后情况稳定,随访超过2年无肿瘤复发。在资源匮乏地区对LMS进行诊断并开展手术及辅助治疗具有挑战性。这是由于缺乏全民医保覆盖。采用多学科方法进行早期诊断并完整切除肿瘤,为提高生存率和生活质量提供了最有利的可能性。