Wadi Nida M A, Ahuja Alka, Peh Kok Khiang
College of Pharmacy, National University of Sciences and Technology, Muscat, Oman.
School of Pharmaceutical Science, University of Science Malaysia, Penang, Malaysia.
Oman Med J. 2022 May 31;37(3):e381. doi: 10.5001/omj.2022.66. eCollection 2022 May.
We sought to investigate the healing efficacy of thermosensitive in situ gelling formulation containing metronidazole and diclofenac potassium on ligature-induced periodontitis (LIP) in rats.
We used 30 adult male Sprague-Dawley rats; 24 rats were subjected to LIP, while the remaining six rats were used as control. The 24 rats with LIP were subdivided into four groups of six rats each. Group 1 received 5% metronidazole loaded gel, group 2 received 0.2% diclofenac potassium loaded gel, group 3 received 5% metronidazole and 0.2% diclofenac potassium, and group 4 (the control group) did not receive any treatment. Treatment was administered on day 0, and the rats were monitored over seven days. Specimens were collected for histological examination to assess the healing process.
We found a statistically significant difference ( < 0.050) in the inflammatory and repair parameters of the healing process between different treatments. Combining the two drugs significantly accelerated the healing compared to the drugs given alone.
Using a combination of diclofenac and metronidazole could potentially accelerate the healing process compared to the use of a single drug of either diclofenac or metronidazole.
我们旨在研究含甲硝唑和双氯芬酸钾的热敏原位凝胶制剂对大鼠结扎性牙周炎（LIP）的愈合疗效。
我们使用了30只成年雄性Sprague-Dawley大鼠；24只大鼠接受结扎性牙周炎手术，其余6只大鼠作为对照。24只患有结扎性牙周炎的大鼠被分为四组，每组6只。第1组接受含5%甲硝唑的凝胶，第2组接受含0.2%双氯芬酸钾的凝胶，第3组接受含5%甲硝唑和0.2%双氯芬酸钾的凝胶，第4组（对照组）不接受任何治疗。在第0天进行治疗，并对大鼠进行7天的监测。收集标本进行组织学检查以评估愈合过程。
我们发现不同治疗方法在愈合过程的炎症和修复参数方面存在统计学显著差异（<0.050）。与单独给药相比，两种药物联合使用显著加速了愈合。
与单独使用双氯芬酸或甲硝唑中的一种药物相比，联合使用双氯芬酸和甲硝唑可能会加速愈合过程。
