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牙周炎:一种累及牙齿支持组织的多因素疾病。

Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues.

作者信息

Könönen Eija, Gursoy Mervi, Gursoy Ulvi Kahraman

机构信息

Department of Periodontology, Institute of Dentistry, University of Turku, 20520 Turku, Finland.

Oral Health Care, Welfare Division, City of Turku, 20101 Turku, Finland.

出版信息

J Clin Med. 2019 Jul 31;8(8):1135. doi: 10.3390/jcm8081135.

DOI:10.3390/jcm8081135
PMID:31370168
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6723779/
Abstract

Periodontitis is an infection-driven inflammatory disease in which the composition of biofilms plays a significant role. Dental plaque accumulation at the gingival margin initiates an inflammatory response that, in turn, causes microbial alterations and may lead to drastic consequences in the periodontium of susceptible individuals. Chronic inflammation affects the gingiva and can proceed to periodontitis, which characteristically results in irreversible loss of attachment and alveolar bone. Periodontitis appears typically in adult-aged populations, but young individuals can also experience it and its harmful outcome. Advanced disease is the major cause of tooth loss in adults. In addition, periodontitis is associated with many chronic diseases and conditions affecting general health.

摘要

牙周炎是一种由感染引发的炎症性疾病,其中生物膜的组成起着重要作用。牙龈边缘处牙菌斑的堆积引发炎症反应,进而导致微生物群落改变,并可能在易感个体的牙周组织中引发严重后果。慢性炎症会影响牙龈,并可能发展为牙周炎,其典型特征是附着丧失和牙槽骨不可逆性吸收。牙周炎通常出现在成年人群体中,但年轻人也可能患病并出现有害后果。晚期牙周炎是成年人牙齿缺失的主要原因。此外,牙周炎还与许多影响全身健康的慢性疾病和状况相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e7c/6723779/3da4ff4e6403/jcm-08-01135-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e7c/6723779/9de3757b7201/jcm-08-01135-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e7c/6723779/3da4ff4e6403/jcm-08-01135-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e7c/6723779/9de3757b7201/jcm-08-01135-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e7c/6723779/3da4ff4e6403/jcm-08-01135-g002.jpg

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Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis.类风湿关节炎患者的牙周健康与口腔微生物群
J Clin Med. 2019 May 8;8(5):630. doi: 10.3390/jcm8050630.
2
Hypoxia-induced endothelial cell responses - possible roles during periodontal disease.缺氧诱导的内皮细胞反应——在牙周病中的可能作用
Clin Exp Dent Res. 2018 Dec 14;4(6):241-248. doi: 10.1002/cre2.135. eCollection 2018 Dec.
3
Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides.细菌环二核苷酸对牙龈上皮细胞因子反应的调节
通过整合机器学习和生物信息学分析探索脂质代谢相关基因和免疫微环境在牙周炎中的作用。
Sci Rep. 2025 Aug 16;15(1):30008. doi: 10.1038/s41598-025-15330-z.
4
In vitro study of probiotic Lactobacillus helveticus: Antibacterial effects on Porphyromonas gingivalis.益生菌瑞士乳杆菌的体外研究:对牙龈卟啉单胞菌的抗菌作用
PLoS One. 2025 Aug 8;20(8):e0329497. doi: 10.1371/journal.pone.0329497. eCollection 2025.
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Evaluating Dickkopf-1 as a biomarker: insights into periodontitis, rheumatoid arthritis, and their comorbidity-a systematic review and meta-analysis.评估Dickkopf-1作为生物标志物:对牙周炎、类风湿性关节炎及其合并症的见解——一项系统综述和荟萃分析
Front Dent Med. 2025 Jul 21;6:1593218. doi: 10.3389/fdmed.2025.1593218. eCollection 2025.
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Determine the accuracy of CBCT reconstructed panoramic images in periodontal assessment.确定锥形束计算机断层扫描(CBCT)重建全景图像在牙周评估中的准确性。
PLoS One. 2025 Jul 31;20(7):e0329604. doi: 10.1371/journal.pone.0329604. eCollection 2025.
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