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胎粪性腹膜炎、肠闭锁合并胆道闭锁:一例报告

Meconium Peritonitis, Intestinal Atresia Combined With Biliary Atresia: A Case Report.

作者信息

Han Yijiang, Hu Shuqi, Chen Baohai, Huang Shoujiang, Qin Qi, Tou Jinfa

机构信息

Department of Neonatal Surgery, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.

Department of Information Center, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.

出版信息

Front Pediatr. 2022 Jun 2;10:917116. doi: 10.3389/fped.2022.917116. eCollection 2022.

Abstract

Meconium peritonitis (MP) combined with intestinal atresia (IA) is a rare neonatal condition, and it is even rarer in combination with biliary atresia (BA). We describe a case of an infant who developed short bowel syndrome after partial intestinal resection due to MP and IA, along with a Santullienterostomy. During continuous enteral and parenteral nutrition, the stool color became paler. BA was identified by elevated direct bilirubin (DBIL), gamma-glutamyltransferase (GGT), serum matrix metalloproteinase-7 (MMP-7), and hepatobiliary ultrasound; then, Kasai portoenterostomy (KPE) was performed promptly. The Roux-en-Y limb was adjusted intraoperatively to preserve the maximum length of the small intestine while closing the enterostomy. After the operation, the infant gradually adapted to enteral nutrition, his bilirubin level returned to normal, and his weight gradually caught up to the normal range. Although rare, BA should be suspected when MP is combined with IA and when the stool becomes paler in color in the enterostomy state.

摘要

胎粪性腹膜炎(MP)合并肠闭锁(IA)是一种罕见的新生儿疾病,而合并胆道闭锁(BA)则更为罕见。我们描述了一例因MP和IA行部分肠切除术后并发短肠综合征的婴儿病例,同时还进行了Santulli肠造口术。在持续肠内和肠外营养期间,患儿大便颜色变浅。通过直接胆红素(DBIL)、γ-谷氨酰转移酶(GGT)、血清基质金属蛋白酶-7(MMP-7)升高及肝胆超声检查确诊为BA;随后立即进行了Kasai肝门空肠吻合术(KPE)。术中调整Roux-en-Y肠袢以保留小肠的最大长度,同时关闭肠造口。术后,婴儿逐渐适应肠内营养,胆红素水平恢复正常,体重逐渐追赶至正常范围。尽管罕见,但当MP合并IA且肠造口状态下大便颜色变浅时,应怀疑BA。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf9/9201381/41c3d4b20b0b/fped-10-917116-g0001.jpg

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