Department of Pediatrics, Pediatric Liver Center, Digestive Health Institute and Section of Pediatric Gastroenterology, Hepatology & Nutrition Children's Hospital ColoradoUniversity of Colorado School of Medicine Aurora CO USA.
Liver Transpl. 2022 Mar;28(3):483-492. doi: 10.1002/lt.26339. Epub 2021 Nov 10.
Children with biliary atresia (BA), particularly infants, are at high risk for malnutrition attributed to a multitude of factors, including poor oral intake and intolerance of enteral feeding, fat malabsorption, abnormal nutrient metabolism, and increased caloric demand. Malnutrition and sarcopenia negatively impact outcomes in BA, leading to higher pretransplant and posttransplant morbidity and mortality. This review summarizes factors contributing to nutritional deficiencies in BA and offers an organized approach to the assessment and management of malnutrition in this vulnerable population.
胆道闭锁（BA）患儿，尤其是婴儿，由于多种因素存在发生营养不良的高风险，包括摄食不良和不耐受肠内喂养、脂肪吸收不良、营养素代谢异常以及热量需求增加。营养不良和肌肉减少症对 BA 的结局产生负面影响，导致更高的移植前和移植后发病率和死亡率。本文综述了导致 BA 营养缺乏的因素，并为这一脆弱人群的营养不良评估和管理提供了一种有组织的方法。
