Han Tiandong, Zhang Li, Jiang Weixing, Wang Lei
Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Front Psychiatry. 2022 Jun 3;13:917082. doi: 10.3389/fpsyt.2022.917082. eCollection 2022.
The burden of depression in the elderly is increasing worldwide with global aging. However, there is still a lack of research on the relationship between depressive symptoms and the progression of renal function. Our aim is to evaluate the longitudinal association between baseline depressive symptoms and the changes in serum cystatin C levels over 10 years' follow-up period.
We used longitudinal data from the Health and Retirement Study (HRS), an existing community based nationally representative aging cohort study which enrolled individuals over age 50 in the USA. Depressive symptoms were determined using an eight-item version of the Center for Epidemiologic Studies Depression Scale (CESD) at wave 7 (2004) and wave 8 (2006). Persistent depressive symptoms were defined as both CESD scores measured at waves 7 and 8 were ≥3; episodic depressive symptoms were defined as CESD scores ≥3 at wave 7 or wave 8. A linear mixed model was used to evaluate the correlation between baseline depressive symptoms and future changes in cystatin C levels.
The mean age of the 7,642 participants was 63.8 ± 10.8 years, and 60.9% were women. Among the participants, 1,240 (16.2%) had episodic depressive symptoms and 778 (10.2%) had persistent depressive symptoms. Compared with participants with no depressive symptoms at both waves, a significant increase in serum cystatin C levels was found among those with persistent depressive symptoms.
Our results showed that baseline persistent depressive symptoms were significantly associated with an increased rate of serum cystatin C levels. The level of serum cystatin C should be monitored in the elderly with persistent depressive symptoms.
随着全球老龄化，老年人抑郁症的负担在全球范围内不断增加。然而，关于抑郁症状与肾功能进展之间的关系仍缺乏研究。我们的目的是评估在10年随访期内基线抑郁症状与血清胱抑素C水平变化之间的纵向关联。
我们使用了来自健康与退休研究（HRS）的纵向数据，这是一项现有的基于社区的全国代表性老龄化队列研究，在美国纳入了50岁以上的个体。抑郁症状通过在第7波（2004年）和第8波（2006年）使用流行病学研究中心抑郁量表（CESD）的八项版本来确定。持续性抑郁症状定义为第7波和第8波测量的CESD分数均≥3；发作性抑郁症状定义为第7波或第8波的CESD分数≥3。使用线性混合模型来评估基线抑郁症状与未来胱抑素C水平变化之间的相关性。
7642名参与者的平均年龄为63.8±10.8岁，60.9%为女性。在参与者中，1240人（16.2%）有发作性抑郁症状，778人（10.2%）有持续性抑郁症状（。与两波均无抑郁症状的参与者相比，持续性抑郁症状的参与者血清胱抑素C水平显著升高。
我们的结果表明，基线持续性抑郁症状与血清胱抑素C水平升高率显著相关。对于有持续性抑郁症状的老年人，应监测血清胱抑素C水平。
