Sherif M, Aboul-Enein M, Soliman O
J Int Med Res. 1978;6(4):266-70. doi: 10.1177/030006057800600403.
Amikacin was used in the treatment of severe urinary tract infections in twenty-five seriously ill patients. In twenty-four of the patients, cystitis or pyelonephritis complicated carcinoma of the bladder. Structural changes in the urinary tract, resulting from schistosomiasis, presented additional obstacles to treatment in many of the patients. The most commonly isolated pathogens were Escherichia coli and Pseudomonas. Most patients received 500 mg of amikacin every twelve hours. Three patients experienced adverse renal reactions which showed subsequent improvement. Amikacin effected twenty-one (84%) complete cures and four (16%) clinical cures in the twenty-five patients. This represents 100% clinical success in this study.
阿米卡星用于治疗25例重症患者的严重尿路感染。其中24例患者的膀胱炎或肾盂肾炎并发膀胱癌。血吸虫病导致的尿路结构改变给许多患者的治疗带来了额外障碍。最常见的分离病原体是大肠杆菌和假单胞菌。大多数患者每12小时接受500毫克阿米卡星治疗。3例患者出现肾不良反应，随后有所改善。在这25例患者中，阿米卡星实现了21例（84%）完全治愈和4例（16%）临床治愈。这代表了本研究100%的临床成功率。
