Chen Zhenhao, Sun Yunpeng, Wang Yongyue, Kong Lingyi, Luo Jun
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, People's Republic of China.
Nat Prod Res. 2023 Oct-Nov;37(20):3505-3511. doi: 10.1080/14786419.2022.2089670. Epub 2022 Jun 18.
Two new sesquiterpenoids, sarglanoids G and H ( and ), together with two known analogues (-) were isolated from the roots of . Compound was a rare elemene-type sesquiterpenoid with a furan ring fragment, which is mostly lactone ring in its analogues. The structures of new compounds were determined on the basis of extensive spectroscopic methods including HR-ESI-MS, 1D and 2D NMR, and the absolute configuration of was established by ECD calculations. Their anti-inflammatory activities were also evaluated.
从[植物名称]的根部分离出两种新的倍半萜类化合物,即sarglanoids G和H(以及[其他两种已知类似物的名称]),还有两种已知类似物([已知类似物的具体名称])。化合物[具体化合物名称]是一种罕见的带有呋喃环片段的榄香烯型倍半萜类化合物,其类似物大多含有内酯环。通过包括高分辨电喷雾电离质谱(HR-ESI-MS)、一维和二维核磁共振(1D和2D NMR)在内的多种光谱方法确定了新化合物的结构,并通过电子圆二色光谱(ECD)计算确定了[具体化合物名称]的绝对构型。还评估了它们的抗炎活性。