Anti-Inflammatory Lindenane Sesquiterpenoid Dimers from the Roots of .

Sarglaroids A-H (-), eight new lindenane dimers, and a monomer sarglaroid I (), along with fourteen known analogues (-), were isolated from the roots of The planar structures and the absolute configurations were elucidated by HR-MS, NMR, ECD calculations, and X-ray diffraction crystallography. Sarglaroid A () was identified as a rare 8,9- lindenane dimer with a unique 5/5/5 tricyclic system. The biological evaluation showed that compounds and potently inhibited NO production with IC values at 19.8 ± 1.06 and 10.7 ± 0.25 μM, respectively, and had no cytotoxicity to RAW264.7 cells. Compound significantly inhibited the LPS-/ATP-induced IL-1β release by inactivating the NLRP3 inflammasome through inhibiting the initiation and assembly by affecting the K efflux. Compounds and inhibited the proliferation of MCF-7 and MDA-MB-231 with IC values ranging from 5.4 to 10.2 μM.