草珊瑚种子中的倍半萜类化合物及其潜在的抗炎作用。
Sesquiterpenoids from the seeds of Sarcandra glabra and the potential anti-inflammatory effects.
作者信息
Yaermaimaiti Saimijiang, Wang Peng, Luo Jun, Li Rui-Jun, Kong Ling-Yi
机构信息
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China; School of Pharmacy, Yancheng Teachers University, Xiwang Road, Yancheng 224051, People's Republic of China.
出版信息
Fitoterapia. 2016 Jun;111:7-11. doi: 10.1016/j.fitote.2016.03.020. Epub 2016 Apr 2.
Five new sesquiterpenoids, including two linderanes (1-2) and three eudesmanes (3-5) were isolated from the seeds of Sarcandra glabra. Their structures and relative configurations were established by spectroscopic data analysis. 1 was a rare linderane derivative having an 18-membered triester ring which is a common characteristic in linderane dimers. Compounds 1-5 were investigated for their inhibitory effects on NO production in LPS-induced macrophages and 1 showed moderate bioactivity.
从九节茶种子中分离得到五个新的倍半萜类化合物，包括两个乌药烷型倍半萜（1-2）和三个桉叶烷型倍半萜（3-5）。通过光谱数据分析确定了它们的结构和相对构型。化合物1是一种罕见的乌药烷衍生物，具有一个18元三酯环，这是乌药烷二聚体的一个共同特征。对化合物1-5进行了LPS诱导的巨噬细胞中一氧化氮产生抑制作用的研究，化合物1表现出中等生物活性。
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