Alderson M, Nade S
J Orthop Res. 1987;5(2):261-74. doi: 10.1002/jor.1100050213.
An experimental model of acute septic arthritis is described, utilizing the injection of S. aureus into chicken hock joints. The course of the infection was monitored over a 14-day period by measurement of chicken growth rate, histopathology of the joint, number of bacteria, and number and type of leukocytes in the synovial fluid. Bacterial numbers decreased initially then increased rapidly over the first 24 h. Leukocyte counts rose sharply, starting between 60 and 90 min after injection. Gross destruction of articular cartilage was observed at 4 days, and appeared to be initiated by the adherence of the staphylococci to the cartilage surface followed by their penetration and invasion of vascular tunnels in the epiphyseal cartilage. Extensive (but focal) erosion of the articular surface was evident by 14 days.
本文描述了一种急性化脓性关节炎的实验模型，该模型通过向鸡的跗关节注射金黄色葡萄球菌来构建。在14天的时间里，通过测量鸡的生长速率、关节组织病理学、细菌数量以及滑液中白细胞的数量和类型来监测感染过程。细菌数量最初减少，然后在最初的24小时内迅速增加。注射后60至90分钟之间，白细胞计数急剧上升。在第4天观察到关节软骨的严重破坏，这似乎是由葡萄球菌粘附于软骨表面，随后穿透并侵入骨骺软骨中的血管通道所引发的。到第14天，关节表面出现广泛（但为局灶性）侵蚀。
