血液中的循环肿瘤细胞作为舌鳞癌的预后生物标志物。

Circulating tumor cells in blood as a prognostic biomarker in tongue squamous cell carcinoma.

机构信息

Department of Stomatology, The Frist Affiliated Hosptial of Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China.

Department of Stomatology, The Frist Affiliated Hosptial of Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China; Department of Stomatology, Guangzhou Women and Children's Medical Center, Guangzhou, Guangdong, People's Republic of China.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol. 2022 Aug;134(2):213-219. doi: 10.1016/j.oooo.2021.12.129. Epub 2021 Dec 30.

DOI:10.1016/j.oooo.2021.12.129

PMID:35725964

Abstract

OBJECTIVE

The study aimed to evaluate the role of circulating tumor cells (CTCs) as a prognostic biomarker of tongue squamous cell carcinoma (TSCC).

STUDY DESIGN

CTC levels in the peripheral blood of 50 patients with TSCC at baseline (i.e., before treatment) and of 8 healthy donors were determined using the NanoVelcro system. The relationship between CTC levels and clinicopathologic parameters and clinical outcomes such as recurrence, metastasis, and death during follow-up (mean 17 months) was analyzed.

RESULTS

CTCs levels were closely correlated with TSCC clinical staging (P = .002), N staging (P = .007), and progression status (P = .002) in TSCC patients. Receiver operating characteristic (ROC) analysis revealed that the count of CTC ≥4 (area under curve: 0.832 [95% confidence interval 0.695-0.950]; sensitivity: 0.83; specificity: 0.75; P < .001) was a better prognostic marker than TNM stage (area under curve: 0.692 [0.536-0.848]; sensitivity: 0.83; specificity: 0.55; P = .023). In addition, univariate and multivariate analysis showed that the CTC was an important and independent predictive factor for overall survival and disease-free survival (P < .001).

CONCLUSIONS

CTC was an independent prognostic indicator in patients with TSCC. CTC may be used as an auxiliary parameter to predict the prognosis of TSCC.

摘要

目的

本研究旨在评估循环肿瘤细胞（CTC）作为舌鳞状细胞癌（TSCC）预后生物标志物的作用。

研究设计

使用 NanoVelcro 系统检测 50 例基线（即治疗前）TSCC 患者和 8 名健康供体外周血中的 CTC 水平。分析 CTC 水平与临床病理参数以及随访期间（平均 17 个月）复发、转移和死亡等临床结局之间的关系。

结果

CTC 水平与 TSCC 临床分期（P=0.002）、N 分期（P=0.007）和进展状态（P=0.002）密切相关。受试者工作特征（ROC）分析显示，CTC≥4 计数（曲线下面积：0.832[95%置信区间 0.695-0.950]；灵敏度：0.83；特异性：0.75；P<0.001）是比 TNM 分期（曲线下面积：0.692[0.536-0.848]；灵敏度：0.83；特异性：0.55；P=0.023）更好的预后标志物。此外，单因素和多因素分析表明，CTC 是总生存期和无病生存期的重要独立预测因素（P<0.001）。