Rubin C T, Lanyon L E
J Orthop Res. 1987;5(2):300-10. doi: 10.1002/jor.1100050217.
The capacity for functional adaptation within the skeleton was studied using the functionally isolated turkey ulna preparation. The results of this study would suggest that adaptive bone remodeling is extremely sensitive to alterations in both the magnitude and distribution of the strain generated within the bone tissue. At present, it appears that a loading regime can only influence bone remodeling when it is dynamic in nature. The full osteogenic potential of its influence is then achieved after only an extremely short exposure to this stimulus. The potency of the stimulus appears to be proportional to the magnitude of the strain engendered. As strain levels that are acceptable in one location induce adaptive remodeling in others, it would appear that each region of each bone is "genetically programmed" to accept a particular amount and pattern of intermittent strain as "normal." Deviation from this "optimal strain environment" will stimulate changes in the bone's remodeling balance, resulting in adaptive increases or decreases in its mass.
利用功能孤立的火鸡尺骨制剂研究了骨骼内功能适应的能力。这项研究的结果表明，适应性骨重塑对骨组织内产生的应变的大小和分布的改变极为敏感。目前看来，只有当加载方式本质上是动态的时候，它才能影响骨重塑。仅在极短时间暴露于这种刺激后，其影响的全部成骨潜力才能实现。刺激的效力似乎与所产生应变的大小成正比。由于在一个位置可接受的应变水平会在其他位置诱导适应性重塑，似乎每根骨头的每个区域都被“基因编程”为接受特定量和模式的间歇性应变作为“正常”情况。偏离这种“最佳应变环境”将刺激骨重塑平衡的变化，导致其质量适应性增加或减少。
