Skerry T M, Bitensky L, Chayen J, Lanyon L E
Department of Anatomy, Royal Veterinary College, London, England.
J Orthop Res. 1988;6(4):547-51. doi: 10.1002/jor.1100060411.
The load-carrying capacity of the skeleton is achieved and maintained as the result of a continued functional stimulus to the cell populations responsible for bone remodeling. Although some bone cells have been assumed to be influenced by the load-induced changes in strain throughout the matrix, no evidence is available to indicate which cells are susceptible to such strain change or how such transient events provide a sustained influence on cell behaviour. In the present study, we showed that a short period of dynamic loading in vivo affects the orientation of proteoglycan within bone tissue. This reorientation declines only slowly, thus providing a persistent record of the tissue's recent strain history. Such a record has the ability not only to "capture" strain transients but also to "update" and "average" them. In this way, the bone cells could be presented with a sustained and coherent stimulus directly related to dynamic strain transients. These transients are the tissue's principal function variable.
骨骼的承载能力是对负责骨重塑的细胞群体持续施加功能刺激的结果并得以维持。尽管一些骨细胞被认为会受到整个基质中负荷诱导的应变变化的影响，但尚无证据表明哪些细胞易受这种应变变化的影响，也没有证据表明这种短暂事件如何对细胞行为产生持续影响。在本研究中，我们表明体内短时间的动态负荷会影响骨组织中蛋白聚糖的取向。这种重新取向仅缓慢下降，从而提供了组织近期应变历史的持久记录。这样的记录不仅能够“捕捉”应变瞬变，还能够对其进行“更新”和“平均”。通过这种方式，骨细胞可以接收到与动态应变瞬变直接相关的持续且连贯的刺激。这些瞬变是组织的主要功能变量。
