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基底细胞癌:当代诊断与治疗的叙述性综述

Basal Cell Carcinoma: A Narrative Review on Contemporary Diagnosis and Management.

作者信息

Naik Piyu Parth, Desai Munaf B

机构信息

European Board of Dermatology and Venereology (UEMS-EBDV), Specialist Dermatologist, Medical Director, Department of Dermatology, Saudi-German Hospital and Clinic, Opposite Burj Al Arab, Dubai, UAE.

Department of Histopathology, University Hospital Dorset NHS Foundation Trust, Bournemouth, UK.

出版信息

Oncol Ther. 2022 Dec;10(2):317-335. doi: 10.1007/s40487-022-00201-8. Epub 2022 Jun 21.

Abstract

Basal cell carcinoma (BCC) is the most common, accounting for 80-90% of skin cancers. It arises from the basal layer of the epidermis and its appendages. A complex interplay of environmental, phenotypic and genetic variables leads to the development of BCC. Literature has documented several clinical subtypes of BCC, the most common of which are nodular, superficial and morpheaform. Expeditious diagnosis and analysis are essential for improving the outcome of BCC. Preventive measures, particularly when implemented in childhood and adolescence, may play a critical role. Due to its low metastatic potential, treatment for BCC mostly focuses on local management. The standard treatment of basal cell carcinoma involved complete removal of the lesion by excision or Mohs surgery. In special circumstances, basal cell carcinoma can be treated with cryosurgery, electrodesiccation and curettage, topical medications and photodynamic therapy. This review aimed to evaluate the contemporary diagnosis and management of basal cell carcinoma.

摘要

基底细胞癌(BCC)是最常见的皮肤癌,占皮肤癌的80-90%。它起源于表皮及其附属器的基底层。环境、表型和遗传变量之间复杂的相互作用导致了基底细胞癌的发生。文献记载了基底细胞癌的几种临床亚型,其中最常见的是结节型、表浅型和硬斑病样型。快速诊断和分析对于改善基底细胞癌的治疗结果至关重要。预防措施,尤其是在儿童和青少年时期实施时,可能会发挥关键作用。由于其转移潜能较低,基底细胞癌的治疗主要集中在局部处理。基底细胞癌的标准治疗方法是通过切除或莫氏手术完全切除病变。在特殊情况下,基底细胞癌可以用冷冻手术、电干燥刮除术、外用药物和光动力疗法治疗。本综述旨在评估基底细胞癌的当代诊断和治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f4c/9681969/5a51af19f447/40487_2022_201_Fig1_HTML.jpg

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