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新型冠状病毒（SARS-CoV-2）的结构、基因组信息及计算分析

Structural, genomic information and computational analysis of emerging coronavirus (SARS-CoV-2).

作者信息

Agarwal Deepak, Zafar Imran, Ahmad Syed Umair, Kumar Sujit, Ain Qurat Ul, Sundaray Jitendra Kumar, Rather Mohd Ashraf

机构信息

Tamil Nadu Dr. Jayalalithaa Fisheries University-IFPGS, OMR Campus, Vaniyanchavadi, Chennai, India.

Department of Bioinformatics and Computational Biology, Virtual University Punjab, Lahore, Pakistan.

出版信息

Bull Natl Res Cent. 2022;46(1):170. doi: 10.1186/s42269-022-00861-6. Epub 2022 Jun 15.

DOI:10.1186/s42269-022-00861-6
PMID:35729950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9199328/
Abstract

BACKGROUND

The emerging viral pandemic worldwide is associated with a novel coronavirus, SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). This virus is said to emerge from its epidemic center in Wuhan, China, in 2019. Coronaviruses (CoVs) are single-stranded, giant, enveloped RNA viruses that come under the family of coronaviridae and order Nidovirales which are the crucial pathogens for humans and other vertebrates.

MAIN BODY

Coronaviruses are divided into several subfamilies and genera based on the genomic structure and phylogenetic relationship. The name corona is raised due to the presence of spike protein on the envelope of the virus. The structural and genomic study revealed that the total genome size of SARS-CoV-2 is from 29.8 kb to 29.9 kb. The spike protein (S) is a glycoprotein that attaches to the receptor of host cells for entry into the host cell, followed by the attachment of virus RNA to the host ribosome for translation. The phylogenetic analysis of SARS-CoV-2 revealed the similarity (75-88%) with bat SARS-like coronavirus.

CONCLUSION

The sign and symptoms of novel severe acute respiratory syndrome coronavirus 2 are also discussed in this paper. The worldwide outbreak and prevention from severe acute respiratory syndrome coronavirus 2 are overviewed in the present article. The latest variant of coronavirus and the status of vaccines are also overviewed in the present article.

摘要

背景

全球新出现的病毒性大流行与一种新型冠状病毒——严重急性呼吸综合征冠状病毒2（SARS-CoV-2）有关。据说这种病毒于2019年在中国武汉的疫情中心出现。冠状病毒是单链、大型、包膜RNA病毒，属于冠状病毒科和尼多病毒目，是人类和其他脊椎动物的重要病原体。

正文

冠状病毒根据基因组结构和系统发育关系分为几个亚科和属。因其病毒包膜上存在刺突蛋白而得名“冠状”。结构和基因组研究表明，SARS-CoV-2的基因组总大小为29.8 kb至29.9 kb。刺突蛋白（S）是一种糖蛋白，它附着于宿主细胞的受体以进入宿主细胞，随后病毒RNA附着于宿主核糖体进行翻译。SARS-CoV-2的系统发育分析显示与蝙蝠SARS样冠状病毒有相似性（75%-88%）。

结论

本文还讨论了新型严重急性呼吸综合征冠状病毒2的体征和症状。本文概述了全球严重急性呼吸综合征冠状病毒2的爆发情况及预防措施。本文还概述了冠状病毒的最新变种和疫苗状况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c6/9199328/a96c71cd97d5/42269_2022_861_Fig6_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c6/9199328/a96c71cd97d5/42269_2022_861_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c6/9199328/dee7fc80a837/42269_2022_861_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c6/9199328/2aba69ec0802/42269_2022_861_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c6/9199328/0e711c90e875/42269_2022_861_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c6/9199328/1675fce1931f/42269_2022_861_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c6/9199328/cb301f5b397d/42269_2022_861_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c6/9199328/a96c71cd97d5/42269_2022_861_Fig6_HTML.jpg

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