Bandarian Fatemeh, Qorbani Mostafa, Nasli-Esfahani Ensieh, Sanjari Mahnaz, Rambod Camelia, Larijani Bagher
Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular- Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Int J Low Extrem Wounds. 2025 Mar;24(1):31-40. doi: 10.1177/15347346221109057. Epub 2022 Jun 21.
This study aimed to review epidemiology of diabetic foot (DF) amputation and provide a pooled estimation of DF amputation rate in the region. A comprehensive search was performed in Web of Science, PubMed, Scopus and EMBASE databases using appropriate search term. Obtained records were entered endnote software and after removing duplicats were screened by title, abstract and full text. Data was extracted from the remained documents. Random effect meta-analysis was used to pool the estimated prevalence rate due to sever heterogeneity between studies. Finally 17 articles in diabetes, 20 in patients with DFU (diabetic foot ulcer) and two in both remained after screening and included in meta-analysis. Overall pooled amputation rate in diabetes was 2% (95% CI: 1%-3%) which was not significantly different between countries. The pooled prevalence of amputation rate in DFU patients was 33% (24%-43%) and the pooled prevalence in Saudi Arabia was significantly higher than in other countries. The estimated rate of foot amputation in diabetes patients and those with DFUs in the Middle East region is approximately high, which may indicate low quality of preventive foot care, low socioeconomics and low patients awareness or education in countries with high amputation rate.
本研究旨在回顾糖尿病足（DF）截肢的流行病学情况，并对该地区的DF截肢率进行汇总估计。使用适当的检索词在Web of Science、PubMed、Scopus和EMBASE数据库中进行了全面检索。将获取的记录录入EndNote软件，去除重复记录后，通过标题、摘要和全文进行筛选。从剩余文档中提取数据。由于研究之间存在严重异质性，因此采用随机效应荟萃分析来汇总估计患病率。最后，筛选后有17篇关于糖尿病的文章、20篇关于糖尿病足溃疡（DFU）患者的文章以及2篇同时涉及两者的文章被纳入荟萃分析。糖尿病患者的总体汇总截肢率为2%（95%置信区间：1%-3%），各国之间无显著差异。DFU患者截肢率的汇总患病率为33%（24%-43%），沙特阿拉伯的汇总患病率显著高于其他国家。中东地区糖尿病患者和DFU患者的足部截肢估计率较高，这可能表明在截肢率高的国家，预防性足部护理质量低、社会经济水平低以及患者意识或教育程度低。
