Klein E, Montalvo J G, Wawro R, Holland F F, Lebeouf A
Int J Artif Organs. 1978 May;1(3):116-22.
An ammonium ion-specific electrode system is evaluated for analysis of blood urea nitrogen from serum, plasma ultrafiltrate, or hemodialyzer dialysate fluid. The electrode shows a high sensitivity over clinically useful concentration ranges. Free serum ammonia, volatile amines, or urea ammonia after hydrolysis can be measured. In a double blind study excellent correlation was found for 187 blood urea nitrogen samples measured with the electrode with standard auto-analyzer techniques. Continuous monitoring of urea in dialysate fluid is described. Urea clearances were measured from dialysate effluent from an in vitro dialysis using conventional equipment. These values show excellent correlation to those from stnadard analysis methods. A continuous urea sensor for on-line hemodialysis application which can provide quantification of therapy is described.
评估了一种铵离子特异性电极系统，用于分析血清、血浆超滤液或血液透析器透析液中的血尿素氮。该电极在临床上有用的浓度范围内显示出高灵敏度。可以测量游离血清氨、挥发性胺或水解后的尿素氨。在一项双盲研究中，发现用该电极测量的187份血尿素氮样本与标准自动分析仪技术之间具有良好的相关性。描述了对透析液中尿素的连续监测。使用传统设备从体外透析的透析液流出物中测量尿素清除率。这些值与标准分析方法的值显示出良好的相关性。描述了一种用于在线血液透析应用的连续尿素传感器，它可以提供治疗的量化。
