Ronco C, Brendolan A, Crepaldi C, Frisone P, Ghiotto F, Zamboni S, Gastaldon F, La Greca G
Department of Nephrology, Ospedale San Bortolo, Vicenza, Italy.
Int J Artif Organs. 1995 Sep;18(9):534-43.
The aim of this study is to present a clinical experience carried out with a new device designed to measure on-line Urea Nitrogen concentration in the effluent dialysate. The Biostat 1000 Urea Monitor (Baxter Healthcare, Dirfield, Ill, USA) was utilized in the present study. The monitor is based on the principle that multiple urea measurements in the dialysate effluent from the dialyzer, permit to built a double exponential regression leading to the urea kinetic parameters of the dialysis session. Data obtained with the Urea Monitor were, in the present study, compared with those obtained by direct measurements carried out in blood and dialysate and by the collection of the whole amount of spent dialysate. The monitor provided an accurate value of predialysis BUN without any blood drawing. Urea kinetics were established from multiple dialysate measurements and no blood drawing was necessary. The double pool kinetics were taken into account and Kt/V, PCR and SRI% obtained were comparable to those obtained from direct measurement. Since a projected value of Kt/V can be obtained, the monitor could represent a potential source of information to detect possible filter and machine dysfunction, as well as high rate of recirculation.
本研究的目的是展示使用一种新设备进行的临床经验，该设备旨在在线测量透析流出液中的尿素氮浓度。本研究使用了Biostat 1000尿素监测仪（美国伊利诺伊州迪尔菲尔德市百特医疗保健公司）。该监测仪基于这样的原理：对透析器流出液中的尿素进行多次测量，可建立双指数回归，从而得出透析过程的尿素动力学参数。在本研究中，将使用尿素监测仪获得的数据与通过直接测量血液和透析液以及收集全部用过的透析液所获得的数据进行比较。该监测仪无需采血即可提供准确的透析前血尿素氮值。通过多次透析液测量建立尿素动力学，无需采血。考虑了双池动力学，获得的Kt/V、PCR和SRI%与直接测量获得的结果相当。由于可以获得Kt/V的预测值，该监测仪可能是检测可能的滤器和机器功能障碍以及高再循环率的潜在信息来源。
