State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
Biomater Sci. 2022 Jul 26;10(15):4193-4207. doi: 10.1039/d2bm00672c.
The pressure of antimicrobial resistance has forced many countries to reduce or even prohibit the use of antibiotics in feed. Therefore, it is an urgent need to develop alternatives to antibiotics to control infectious diseases in feed and aquaculture. To address this long-lasting challenge, we prepared peptide polymers that display potent and broad-spectrum activity against common pathogenic bacteria in aquaculture, low hemolysis and low cytotoxicity, and do not induce bacteria to develop resistance or cross-resistance to antibiotics. The optimal peptide polymer demonstrates strong therapeutic potential in an adult zebrafish infection model. Moreover, the optimal peptide polymer is biodegradable by enzymes into single amino acids and dipeptides to totally lose its antibacterial activity and, therefore, will not cause antimicrobial selective pressure. Our study suggests that peptide polymers are promising alternatives to antibiotics in aquaculture and open new avenues to address the global challenge of antimicrobial resistance.
抗菌药物耐药性的压力迫使许多国家减少甚至禁止在饲料中使用抗生素。因此，开发抗生素替代品来控制饲料和水产养殖中的传染病是当务之急。为了应对这一持久的挑战，我们制备了显示出针对水产养殖中常见病原菌的强大和广谱活性、低溶血和低细胞毒性、并且不会诱导细菌对抗生素产生耐药性或交叉耐药性的肽聚合物。最佳的肽聚合物在成体斑马鱼感染模型中显示出强大的治疗潜力。此外，最佳的肽聚合物可被酶降解成单个氨基酸和二肽，从而完全失去其抗菌活性，因此不会造成抗菌药物选择压力。我们的研究表明，肽聚合物是水产养殖中抗生素的有前途的替代品，为应对全球抗菌药物耐药性挑战开辟了新途径。
