Liu Junheng, Li Qiongya, Shao Ying, Sun Jiangtao
Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China.
Org Lett. 2022 Jul 1;24(25):4670-4674. doi: 10.1021/acs.orglett.2c01818. Epub 2022 Jun 22.
A highly efficient rhodium-catalyzed formal C-H insertion reaction between indoles and 1-diazonaphthoquinones has been established, providing a novel protocol for the atroposelective synthesis of axially chiral C2-arylindoles (up to 99:1 er) under mild reaction conditions. Typically, only 1 mol % of Rh(-PTTL) is used and the chelation group is not needed for this conversion.
已建立了一种高效的铑催化吲哚与1-重氮萘醌之间的形式C-H插入反应，为在温和反应条件下对映选择性合成轴手性C2-芳基吲哚（对映体过量高达99:1）提供了一种新方法。通常，仅使用1 mol%的Rh(-PTTL)，且该转化过程不需要螯合基团。
