通过铑催化的 C-H 插入反应实现 N-N 轴向手性联吡啶的对映选择性合成。
Atroposelective Synthesis of N-N Axially Chiral Bipyrroles via Rhodium-Catalyzed C-H Insertion Reaction.
机构信息
Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China.
出版信息
Org Lett. 2023 Jul 7;25(26):4808-4812. doi: 10.1021/acs.orglett.3c01509. Epub 2023 Jun 27.
PMID:37366557
Abstract
An atroposelective synthesis of bipyrroles with an axially chiral N-N bond has been established via a rhodium-catalyzed C-H bond insertion reaction to provide the desired atropisomers in good yields (up to 97% yield) with good to excellent enantioselectivities (up to 99% ee).
摘要
通过铑催化的 C-H 键插入反应，建立了具有轴手性 N-N 键的联吡啶的对映选择性合成方法，以良好的收率（高达 97%）和优异的对映选择性（高达 99%ee）提供所需的对映异构体。
Zotero 插件