Davies D W, Walsh L C, Hiteshew M E, Ménache M G, Miller F J, Grose E C
J Toxicol Environ Health. 1987;21(1-2):89-97. doi: 10.1080/15287398709531004.
An automated animal inhalation exposure facility was designed to conduct chronic exposures of rodents to gaseous pollutants. The facility consisted of 3 walk-in chambers with modular cages to allow for exposure of up to a maximum of 480 mice or 240 adult rats. Critical parameters of operation, such as relative humidity, pollutant concentration, and temperature, were monitored continuously. Failure of the system to maintain parameters within specified limits activated the alarm system. Distribution of test gases in the chambers was evaluated for homogeneity, and the standard deviation was determined to be within +/- 5% of the target concentrations throughout the chamber. The exposure facility was successfully used to expose 720 rats to diurnal patterns of O3 (baseline of 0.06 ppm for 13 h with an exposure peak to 0.25 ppm over 9 h) and NO2 (baseline of 0.5 ppm for 16 h with an exposure peak to 1.5 ppm over 6 h) for a period of 18 mo.
设计了一种自动化动物吸入暴露设施，用于对啮齿动物进行气态污染物的慢性暴露。该设施由3个步入式舱室组成，带有模块化笼子，最多可容纳480只小鼠或240只成年大鼠进行暴露实验。对操作的关键参数，如相对湿度、污染物浓度和温度进行连续监测。如果系统未能将参数维持在规定限度内，警报系统就会启动。评估了试验气体在舱室内的分布均匀性，确定整个舱室内的标准偏差在目标浓度的+/-5%范围内。该暴露设施成功地用于让720只大鼠暴露于臭氧（13小时基线为0.06 ppm，9小时内暴露峰值为0.25 ppm）和二氧化氮（16小时基线为0.5 ppm，6小时内暴露峰值为1.5 ppm）的昼夜模式下，为期18个月。
