Zhang Xiang, Tu Yuqing, Shen Juan, Feng Yufeng, Ma Houshi, Bai Lian, Li Xiaoli, Lin Zhihong, Dai Lijun, Gong Feiran, Lu Tianyu, Zhou Jiazi, Chen Hanqing, Lv Quansheng, Zhu Ziling, Ruan Changgeng
National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
Leuk Lymphoma. 2022 Nov;63(11):2636-2644. doi: 10.1080/10428194.2022.2086246. Epub 2022 Jun 22.
Leukapheresis is an effective adjuvant therapy for leukemia patients with hyperleukocytosis, but few studies have reported recent data with modern modalities and comparisons among different leukemia types. We conducted a retrospective study on leukapheresis among 420 patients with AML, ALL and CML in four local centers. WBC counts decreased significantly ( < 0.001) postleukapheresis in all three cohorts. Clearance efficiency was higher in acute leukemia patients than CML patients ( < 0.01). Concomitant leukocytoreduction drugs improved WBC reduction only in AML patients ( < 0.05). Leukocyte, hemoglobin and platelet levels preleukapheresis might affect the clearance efficiency in AML and/or ALL patients. Hematological toxicities were the major concerns, but most of them were mild, and only 11 patients died of all causes within one week postleukapheresis. In conclusion, leukapheresis can safely reduce the leukemic burden, especially for patients with acute leukemias.
白细胞去除术是治疗高白细胞血症白血病患者的一种有效辅助疗法，但很少有研究报告现代方法的近期数据以及不同白血病类型之间的比较。我们对四个当地中心的420例急性髓系白血病（AML）、急性淋巴细胞白血病（ALL）和慢性粒细胞白血病（CML）患者进行了白细胞去除术的回顾性研究。在所有三个队列中，白细胞去除术后白细胞计数显著下降（<0.001）。急性白血病患者的清除效率高于慢性粒细胞白血病患者（<0.01）。联合使用白细胞去除药物仅在急性髓系白血病患者中改善了白细胞减少情况（<0.05）。白细胞去除术前的白细胞、血红蛋白和血小板水平可能会影响急性髓系白血病和/或急性淋巴细胞白血病患者的清除效率。血液学毒性是主要关注点，但大多数毒性较轻，白细胞去除术后一周内仅有11例患者死于各种原因。总之，白细胞去除术可以安全地减轻白血病负担，尤其是对于急性白血病患者。
