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White blood cell count levels are associated with inflammatory response and constitute independent outcome predictors in adult patients with acute myeloid leukemia aged <60 years.白细胞计数水平与炎症反应相关，并且是年龄小于60岁的成年急性髓系白血病患者独立的预后预测指标。
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Risk factors for outcome in refractory acute myeloid leukemia patients treated with a combination of fludarabine, cytarabine, and amsacrine followed by a reduced-intensity conditioning and allogeneic stem cell transplantation.接受氟达拉滨、阿糖胞苷和安吖啶联合治疗后进行减低强度预处理及异基因干细胞移植的难治性急性髓系白血病患者预后的危险因素。
J Cancer Res Clin Oncol. 2016 Jan;142(1):317-24. doi: 10.1007/s00432-015-2050-y. Epub 2015 Sep 30.
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Clinical Characteristics and Outcomes of Acute Myeloid Leukemia Patients Harboring Triple Mutations and the Potential Prognostic Value of .携带三重突变的急性髓系白血病患者的临床特征与预后及……的潜在预后价值
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J Cancer Res Clin Oncol. 2017 Feb;143(2):337-345. doi: 10.1007/s00432-016-2290-5. Epub 2016 Oct 24.
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Better Response and Prognosis of Venetoclax Plus Hypomethylating Agents Over Intensive Chemotherapy in Young Adults With Newly Diagnosed ASXL1-Mutated Acute Myeloid Leukemia.在新诊断的ASXL1突变型急性髓系白血病年轻成人患者中，维奈托克联合去甲基化药物比强化化疗有更好的反应和预后。
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Cytarabine Pharmacogenomics and Outcomes Among Children and Young Adults With Acute Myeloid Leukemia.阿糖胞苷的药物基因组学与急性髓系白血病儿童及青年患者的预后
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本文引用的文献

1
Symptomatic Patients with Hyperleukocytic FLT3-ITD Mutated Acute Myeloid Leukemia Might Benefit from Leukapheresis.有症状的伴有FLT3-ITD突变的高白细胞急性髓系白血病患者可能从白细胞单采术中获益。
Cancers (Basel). 2023 Dec 21;16(1):58. doi: 10.3390/cancers16010058.
2
Effectiveness of leukapheresis on early survival in acute myeloid leukemia: An observational propensity score matching cohort study.
J Clin Apher. 2023 Dec;38(6):727-737. doi: 10.1002/jca.22090. Epub 2023 Oct 3.
3
An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia.炎症状态重塑免疫微环境并改善急性髓系白血病的风险分层。
Nat Cancer. 2023 Jan;4(1):27-42. doi: 10.1038/s43018-022-00480-0. Epub 2022 Dec 29.
4
Molecular cytogenetics in acute myeloid leukemia in adult patients: practical implications.成人急性髓细胞白血病的分子细胞遗传学：实际意义。
Pol Arch Intern Med. 2022 Aug 22;132(7-8). doi: 10.20452/pamw.16300. Epub 2022 Jul 18.
5
Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN.成人 AML 的诊断与治疗：ELN 专家组代表发布的 2022 年国际专家建议
Blood. 2022 Sep 22;140(12):1345-1377. doi: 10.1182/blood.2022016867.
6
Post-remission outcomes in AML patients with high hyperleukocytosis and inaugural life-threatening complications.高白细胞血症初发伴危及生命并发症的 AML 患者缓解后的结局。
PLoS One. 2022 Jul 7;17(7):e0270744. doi: 10.1371/journal.pone.0270744. eCollection 2022.
7
Effectiveness and safety of leukapheresis in hyperleukocytic leukemias: a retrospective multicenter study.白细胞单采术治疗高白细胞血症的有效性和安全性：一项回顾性多中心研究
Leuk Lymphoma. 2022 Nov;63(11):2636-2644. doi: 10.1080/10428194.2022.2086246. Epub 2022 Jun 22.
8
Management of hyperleukocytosis and impact of leukapheresis among patients with acute myeloid leukemia (AML) on short- and long-term clinical outcomes: a large, retrospective, multicenter, international study.急性髓系白血病（AML）患者高白细胞血症的管理及白细胞单采术对短期和长期临床结局的影响：一项大型、回顾性、多中心、国际研究
Leukemia. 2020 Dec;34(12):3149-3160. doi: 10.1038/s41375-020-0783-3. Epub 2020 Mar 4.
9
The mutational oncoprint of recurrent cytogenetic abnormalities in adult patients with de novo acute myeloid leukemia.初发急性髓系白血病成年患者复发性细胞遗传学异常的突变肿瘤印记
Leukemia. 2017 Oct;31(10):2211-2218. doi: 10.1038/leu.2017.86. Epub 2017 Mar 24.
10
Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia.急性髓系白血病驱动基因突变的频谱及预后相关性。
Blood. 2016 Aug 4;128(5):686-98. doi: 10.1182/blood-2016-01-693879. Epub 2016 Jun 10.

White blood cell count levels are associated with inflammatory response and constitute independent outcome predictors in adult patients with acute myeloid leukemia aged <60 years.

作者信息

Ozga Michael, Nicolet Deedra, Mrózek Krzysztof, Walker Christopher J, Blachly James S, Kohlschmidt Jessica, Orwick Shelley, Carroll Andrew J, Larson Richard A, Kolitz Jonathan E, Powell Bayard L, Stone Richard M, Byrd John C, Eisfeld Ann-Kathrin, Mims Alice S

机构信息

The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

出版信息

Am J Hematol. 2024 Nov;99(11):2236-2240. doi: 10.1002/ajh.27465. Epub 2024 Sep 16.

DOI:10.1002/ajh.27465
PMID:39283025
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11469947/
Abstract
摘要